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Modern Microbial Genetics, 2nd Edition

ISBN: 978-0-471-38665-0
657 pages
February 2002
Modern Microbial Genetics, 2nd Edition (0471386650) cover image


In accordance with its predecessor, the completely revised and expanded Second Edition of Modern Microbial Genetics focuses on how bacteria and bacteriophage arrange and rearrange their genetic material through mutation, evolution, and genetic exchange to take optimal advantage of their environment.

The text is divided into three sections: DNA Metabolism, Genetic Response, and Genetic Exchange. The first addresses how DNA replicates, repairs itself, and recombines, as well as how it may be manipulated. The second section is devoted to how microorganisms interact with their environment, including chapters on sporulation and stress shock, and the final section contains the latest information on classic exchange mechanisms such as transformation and conjugation.

Chapters include:

  • Gene Expression and Its Regulation
  • Single-Stranded DNA Phages
  • Genetic Tools for Dissecting Motility and Development of Myxococcus xanthus
  • Molecular Mechanism of Quorum Sensing
  • Transduction in Gram-Negative Bacteria
  • Genetic Approaches in Bacteria with No Natural Genetic Systems

The editors also cultivate an attention to global regulatory systems throughout the book, elucidating how certain genes and operons in bacteria, defined as regulons, network and cooperate to suit the needs of the bacterial cell. With clear appreciation for the impact of molecular genomics, this completely revised and updated edition proves that Modern Microbial Genetics remains the benchmark text in its field.

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Table of Contents


Preface to the First Edition.




Prokaryotic DNA Replication (W. Firshein).

DNA Repair Mechanisms and Mutagenesis (R. Yasbin).

Gene Expression and Its Regulation (J. Helmann).

Bacteriophage Genetics (B. Guttan & E. Kutter).

Bacteriophage and Its Relatives (R. Hendrix).

Single-Stranded DNA Phages (J. LeClerc).

Restriction-Modification Systems (R. Blumenthal & X. Cheng).

Recombination (S. Levene & K. Huffman).

Molecular Applications (T. Geoghegan).


Genetics of Quorum Sensing Circuitry in Pseudomonas aeruginosa: Implications for Control of Pathogenesis, Biofilm Formation and Antibiotic/Biocide Resistance (D. Hassett, et al.).

Endospore Formation in Bacillus subtilis: An Example of Cell Differentiation by a Bacterium (C. Moran).

Stress Shock (U. Streips).

Genetic Tools for Dissecting Motility and Development of Myxococcus xanthus (P. Hartzell).

Agrobacterium Genetics (W. Ream).

Two-Component Regulation (K. Bayles & D. Fujimoto).

Molecular Mechanisms of Quorum Sensing (C. Fuqua & M. Parsek).


Bacterial Transposons--An Increasingly Diverse Group of Elements (G. Whittle & A. Salyers).

Transformation (U. Streips).

Conjugation (R. Porter).

The Subcellular Entities a.k.a. Plasmids (M. Perlin).

Transduction in Gram-Negative Bacteria (G. Weinstock).

Genetic Approaches in Bacteria with No Natural Genetic Systems (C. Haller & T. DiChristina).

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Author Information

Uldis N. Streips was born in Riga, Latvia and emigrated with his family to the United States in 1951. He received a BS in Chemistry and Biology from Valparaiso University, Valparaiso IN in 1964 and a Ph.D. in Microbiology from Northwestern University in 1969. He did postdoctorate research at Scripps Clinic and Research Foundation, LaJolla, CA, and the University of Rochester School of Medicine, Rochester NY. He has been on the faculty of the University of Louisville, School of Medicine since 1972. His principal research area is microbial genetics and physiology. He has 65 peer-reviewed publications and books and chapters. He has received 14 teaching awards at the University of Louisville. Streips has mentored 15 Ph.D. and 2 M.S. students. He is a Foreign Member of the Latvian Academy of Sciences and the chief officer of the annual Wind River Conference on Prokaryotic Biology. He has run summer workshops for high school teachers for the last 14 years.
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"...provide a clear prospective, often laced with insight and enthusiasm...an informative and very browseable addition to the lab bookshelf..." (Microbiology Today)
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