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Handbook of Comparative Genomics: Principles and Methodology

ISBN: 978-0-471-39128-9
442 pages
February 2003
Handbook of Comparative Genomics: Principles and Methodology (047139128X) cover image


This comprehensive reference covers the comparative methodology involved in studying molecular evolution. Providing a practical introduction to the role of bioinformatics in comparative genomics, this publication further discusses the basic technology used in genome sequencing projects and provides an overview of genome storage databases currently in use.

This timely and cutting-edge text also:

  • Reviews the basic principles of genomics and gene expression analysis
  • Discusses analytic methods in proteomics and transcriptomics
  • Includes a comprehensive list of Web resource
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Table of Contents



The Prokaryotic Genome.




Molecular Biology Techniques for Genomics.

Biological Databases.

Computatonal Methods for the Analysis of Genome Sequence Data.


Molecular Evolution.

Molecular Phylogeny.

Appendix I.
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Author Information

Cecilia Saccone is Professor of Molecular Biology at the University of Bari as well as the chair of the National Research Council (CNR) in Bari, Italy.

Graziano Pesole is a professor in the Department of Physiology and General Biochemistry at the University of Milan, Italy.

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"…an excellent addition to the field of comparative genomics." (ASM News, December 2004)

“...will provide interesting reading and perspective to almost everyone involved in biological sciences.” (Quarterly Review of Biology, March 2004)

"...certainly deserves a place in institutional libraries...depth of material covered is right for the busy scientist...precise and detailed..." (Briefings in Functional Genomics & Proteomics, Vol 2(4), February 2004)

"...this book gives an illuminating look at the study of genomes through their sequence..." (Human Genomics, January 2004)

"...covers basic and applied problems in the emerging field of comparative functional genomics..." (Genetic Engineering News, Vol 23(14), 2003)

"Handbook of Comparative Genomics is a pioneering composition illuminating the emerging scientific discipline of comparative evolutionary genomics. Professors Cecilia Saccone and Graziano Pesole have not only provided us with a treasure trove of molecular, structural and compositional information, but more importantly, they have produced a scholarly exegesis of empirical, statistical, bioinformatical, computational, and evolutionary methodology. The Handbook contains both introductory and advanced material, and manages to maintain a degree of lucidity that is as rare as it is indispensable in scientific discourse."
—Dan Graur, Ph.D., Gordon Professor of Life Sciences, Tel Aviv University

"...a unique and most welcome source of information and inspiration for anyone interested in genomics, from advanced undergraduates to experienced researchers."
—Wilfried W. de Jong, Ph.D., Department of Biochemistry, University of Nijmegen, The Netherlands

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