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LC/MS Applications in Drug Development

ISBN: 978-0-471-40520-7
256 pages
March 2002
LC/MS Applications in Drug Development (0471405205) cover image
Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:
  • Proteomics
  • Glycoprotein Mapping
  • Natural Products Dereplication
  • Lead Identification Screening
  • Open-Access LC/MS
  • In Vitro Drug Screening

Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

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Preface.

Acknowledgments.

Introduction.

Drug Development Overview.

Accelerated Drug Development.

LC/MS Development.

LC/MS Applications.

Future Applications and Prospects.

Perspectives on the Future Growth of LC/MS.

Conclusions.

Glossary.

References.

Index.
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MIKE S. LEE, PhD, is President of Milestone Development Services, a consulting firm specializing in pharmaceutical analysis and drug development strategies. He lives in Newtown, Pennsylvania.
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"…a comprehensive primer and will appeal to laboratory scientists and instructors in the pharmaceutical field…" (Analytical Chemistry, November 2002)

"...describes...applications in each phase of drug development...provides perspective on changes in strategies for pharmaceutical analysis..." (SciTech Book News, Vol. 26, No. 2, June 2002)

"...useful not only for students and scholars of analytical chemistry, but also for managers and other scientists...another fine addition to the Wiley-InterScience Series on Mass Spectrometry, it should be in the collections of all research libraries." (The Chemist, Summer 2003)

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