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Molecular Biology of Circadian Rhythms

Amita Sehgal (Editor)
ISBN: 978-0-471-41824-5
283 pages
April 2004
Molecular Biology of Circadian Rhythms (0471418242) cover image
Modern molecular biology and genetics has enabled significant strides in research on the basic properties of biological rhythms. These advances will, in addition to relevance for understanding of cell and body biochemistry, health, and aging, provide insights into the molecular control of behavior. This comprehensive account of the molecular basis of circadian rhythms will cover the recent advances in addition to providing a solid groundwork in the basic aspects of biological timing.
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Preface.

Acronyms.

PART I: INTRODUCTION TO CIRCADIAN RHYTHMS.

1. General Concepts (Amita Sehgal).

2. Genetic and Molecular Approaches Used to Analyze Rhythms (Amita Sehgal and Jeffrey L. Price).

PART II: MOLECULAR CONTROL OF CIRCADIAN RHYTHMS: ANIMAL MODELS.

3. Drosophila melanogaster: A Model System for Molecular Chronobiology (Jeffrey L. Price).

4. Molecular Analysis of Circadian Rhythms: Nonmammalian Vertebrates (Julie A. Williams).

5. Genetic Basis for Circadian Rhythms in Mammals (John D. Alvarez).

PART III: MOLECULAR CONTROL OF CIRCADIAN RHYTHMS: FROM CYANOBACTERIA TO PLANTS.

6. Circadian Rhythms in Cyanobacteria (Nirnjini Naidoo).

7. Molecular Analysis of Circadian Rhythms in Neurospora (Amita Sehgal).

8. Physiological and Molecular Characteristics of Plant Circadian Clocks (Jose A. Jarillo, Juan Capel, and Anthony R. Cashmore).

PART IV: CIRCADIAN ORGANIZATION IN COMPLEX ORGANISMS.

9. Multiple Oscillators (Jadwiga M. Giebultowicz).

10. Hormonal Rhythms (Peter McNamara).

11. Human Circadian Rhythms (Hans P. A. Van Dongen, Gerard A. Kerkhof, and David F. Dinges).

Index.

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Amita Sehgal received her Ph.D. in Cell and Molecular Biology from Cornell University Medical College. Her postdoctoral training was conducted at Rockefeller University, working on the genetic and molecular basis of circadian rhythms in the fruit fly. She has continued this line of work as an independent investigator at the University of Pennsylvania. She is currently an Associate Professor of Neuroscience and an Associate Investigator of the Howard Hughes Medical Institute.
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"Sehgal has edited a valuable chronicle that will appeal to undergraduates, postgraduates and budding chronobiologists." (Biochemist, December 2008)

“…a good introduction to anyone who is interested in learning about the molecular mechanisms behind circadian rhythms…” (Cell Biochemistry and Function, Vol. 23 (4) July 2005)

"...valuable reading for biological or medical scientists and many practitioners. As a first in its field, the volume is sure to become a classic." (Quarterly Review of Biology, March-May 2005)

"...a timely snapshot of the molecular mechanisms of biological timekeeping as we understand it today." (Genes, Brain and Behavior, March 2005)

"…better than a good book…The Alvarez chapter alone justifies its purchase, and several other excellent chapters are also quite useful." (Clinical Chemistry, January 2005)

“…presents a comprehensive account of the current state of chronobiology, delivering a ready resource for students and practitioners.” (Bio World (Germany), Vol.9, No.5 2004)

"…few other books on this subject are available. The material is on interest event to those not in the area." (Doody's Health Services)

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