Solid-Phase Organic Synthesis
Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:
- Syntheses of guanidines
- Palladium-catalyzed C-C bond forming reactions
- S_nAr reactions for the formation of heterocycles
- Sequence-specific arylalkyne oligomers
- Resin-supported capture agents and other reagents
- Synthesis on pins
- Monitoring of supported reactions using IR
- Solid-phase syntheses of natural product derivatives
Of related interest: Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application, Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.
Palladium-catalyzed Carbon-carbon Bond Formation on Solid Supports (M. Todd & C. Abell).
Benzofused Heterocycles via Solid-phase S_NAr Reactions (M. Schwarz & M. Gallop).
Solid-phase Synthesis of Sequence-specific Phenylacetylene Oligomers (J. Moore, et al.).
Polymer-assisted Solution Phase Methods for Chemical Library Synthesis (D. Flynn, et al.).
Solid-phase Organic Synthesis on Radiation-grafted Polymer Surfaces: Application of SynPhase(TM) Crowns to Multiple Parallel Syntheses (I. James, et al.).
Vibrational Spectroscopy for Optimization of Solid-phase Organic Syntheses (B. Yan).
Recent Advances in Solid-phase Synthesis of Natural Products (L. Wilson).
"This book seeks to highlight and critique key developments in solid-phase organic synthesis...Overall, the book effectively realizes its goal..." (Journal of the American Chemical Society, Vol. 123, No. 7)
"...an excellent starting point for chemists interested in solid-phase organic synthesis. Certainly, this book should be considered as an addition to any medicinal chemists library." (Journal of Medicinal Chemistry Vol. 44, No. 24, 2001)
"...brings together...the latest research in the field, highlighting and reviewing some of the major developments." (Chimie Nouvelle)