Integrated Strategies for Drug Discovery Using Mass Spectrometry

List of Contributors.

Acknowledgements.

1. Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development. (Gary A. Valaskovic and Neil L. Kelleher).

2. Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery. (Marshall M. Siegel).

3. ESI-FTICR as a High Throughput Drug Discovery Platform. (Kristin A. Sannes-Lowery, Lendell L. Cummins, Shuo Chen, Jared J. Drader, and Steven A. Hofstadler).

4. Mass Spectrometry- Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery. (Thomas P. Conrads, Haleem J. Issaq, Josi S. Blonder, and Timothy D. Veenstra).

5. Metabonomic Applications in Toxicity Screening and Disease Diagnosis. (John P. Shockcor and Elaine Holmes).

6. The Central Role of Mass Spectrometry in Natural Products Discovery. (Jeffrey R. Gilbert, Paul Lewer, Dennis O. Duebelbeis, Andrew W. Carr).

7. Application of Mass Spectrometry to Compound Library Generation, Analysis, and Management. (Xueheng Cheng and Jill Hochlowski).

8. A Combinatorial Process for Drug Discovery. (David S. Wagner, Richard W. Wagner, Frank Schoenen, and H. Mario Geysen).

9. Application of Technological Advances in Biotransformation Studies. (Carmen L. Fernàndez-Metzler, Raju Subramanian and Richard C. King).

10. Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery. (Jim Wang, Jack Wang, Margaret Davis, William DeMaio, JoAnn Scatina, and Rasmy Talaat).

11. Advances in High Throughput Quantitative Drug Discovery Bioanalysis. (Bradley L. Ackermann, Michael J. Berna, and Anthony T. Murphy).

12. New Strategies for the Implementation and Support of Bioanalysis in a Drug Metabolism Environment. (Walter A. Korfmacher).

13. An Integrated LC-MS Strategy for Preclinical Candidate Optimization. (Jonathan L. Josephs and Mark Sanders).

14. New Approaches for Method Development and Purification in Lead Optimization. (Yining Zhao and David J. Semin).

15. High Throughput Metabolic and Physicochemical Property Analysis: Strategies and Tactics for Impact on Drug Discovery Success. (Edward H. Kerns and Li Di).

16. Organ Perfusion and Mass Spectrometry. (C. Gerald Curtis, Ben Chien, David Bar-Or, and Kumar Ramu).

17. Sample Preparation for Drug Discovery Bioanalysis.(David A. Wells).

18. Automation. (John D. Laycock and Thomas Hartmann).

Index.