What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd EditionISBN: 978-0-471-47192-9
Hardcover
544 pages
March 2007
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Answers the questions: What are the best tests? What controls should be used? How do you avoid potential hidden pitfalls, false positives and negatives, and lurking artifacts? Which statistical tests can be applied?
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Includes a new chapter on Developmental and Neurodegenerative Diseases, covering mental retardation and inborn errors of metabolism through to Alzheimer's disease and stroke
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Provides brand new coverage of practical recommendations for choosing tasks to evaluate a new mutant line (Putting It All Together), including complete guidelines for high-throughput screening
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Discusses implications of the completion of the mouse genome sequence, microarray technology, new gene delivery methods, stem cell transplantation, proteomics, and high throughput approaches in chemical mutagenesis studies
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Expands discussion to the latest studies in learning and memory, autism and social phobias, olfaction, drug addiction, withdrawal, and spinal cord injury
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Includes numerous new figures showing new behavioral tests, equipment, and data
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Each chapter concludes with extensive, up-to-date references and suggestions for background reading
