Biomedical Optics: Principles and ImagingISBN: 9780471743040
376 pages
May 2007

A solutions manual is available for instructors; to obtain a copy please email the editorial department at ialine@wiley.com.
1. INTRODUCTION.
1.1.Motivation for optical imaging.
1.2.General behavior of light in biological tissue.
1.3.Basic physics of lightmatter interaction.
1.4.Absorption and its biological origins.
1.5.Scattering and its biological origins.
1.6.Polarization and its biological origins.
1.7.Fluorescence and its biological origins.
1.8.Image characterization.
1.9.References.
1.10.Further readings.
1.11.Problems.
2. RAYLEIGH THEORY AND MIE THEORY FOR A SINGLE SCATTERER.
2.1.Introduction.
2.2.Summary of the Rayleigh theory.
2.3.Numerical example of the Rayleigh theory.
2.4.Summary of the Mie theory.
2.5.Numerical example of the Mie theory.
2.6.Appendix 2.A. Derivation of the Rayleigh theory.
2.7.Appendix 2.B. Derivation of the Mie theory.
2.8.References.
2.9.Further readings.
2.10.Problems.
3. MONTE CARLO MODELING OF PHOTON TRANSPORT IN BIOLOGICAL TISSUE.
3.1.Introduction.
3.2.Monte Carlo method.
3.3.Definition of problem.
3.4.Propagation of photons.
3.5.Physical quantities.
3.6.Computational examples.
3.7.Appendix 3.A. Summary of MCML.
3.8.Appendix 3.B. Probability density function.
3.9.References.
3.10.Further readings.
3.11.Problems.
4. CONVOLUTION FOR BROADBEAM RESPONSES.
4.1.Introduction.
4.2.General formulation of convolution.
4.3.Convolution over a Gaussian beam.
4.4.Convolution over a tophat beam.
4.5.Numerical solution to convolution.
4.6.Computational examples.
4.7.Appendix 4.A. Summary of CONV.
4.8.References.
4.9.Further readings.
4.10.Problems.
5. RADIATIVE TRANSFER EQUATION AND DIFFUSION THEORY.
5.1.Introduction.
5.2.Definitions of physical quantities.
5.3.Derivation of the radiative transport equation.
5.4.Diffusion theory.
5.5.Boundary conditions.
5.6.Diffuse reflectance.
5.7.Photon propagation regimes.
5.8.References.
5.9.Further readings.
5.10.Problems.
6. HYBRID MODEL OF MONTE CARLO METHOD AND DIFFUSION THEORY.
6.1.Introduction.
6.2.Definition of problem.
6.3.Diffusion theory.
6.4.Hybrid model.
6.5.Numerical computation.
6.6.Computational examples.
6.7.References.
6.8.Further readings.
6.9.Problems.
7. SENSING OF OPTICAL PROPERTIES AND SPECTROSCOPY.
7.1.Introduction.
7.2.Collimated transmission method.
7.3.Spectrophotometry.
7.4.Obliqueincidence reflectometry.
7.5.Whitelight spectroscopy.
7.6.Timeresolved measurement.
7.7.Fluorescence spectroscopy.
7.8.Fluorescence modeling.
7.9.References.
7.10.Further readings.
7.11.Problems.
8. BALLISTIC IMAGING AND MICROSCOPY.
8.1.Introduction.
8.2.Characteristics of ballistic light.
8.3.Timegated imaging.
8.4.Spatialfrequency filtered imaging.
8.5.Polarizationdifference imaging.
8.6.Coherencegated holographic imaging.
8.7.Optical heterodyne imaging.
8.8.Radon transformation and computed tomography.
8.9.Confocal microscopy.
8.10.Twophoton microscopy.
8.11.Appendix 8.A. Holography.
8.12.References.
8.13.Further readings.
8.14.Problems.
9. OPTICAL COHERENCE TOMOGRAPHY.
9.1.Introduction.
9.2.Michelson interferometry.
9.3.Coherence length and coherence time.
9.4.Timedomain OCT.
9.5.Fourierdomain rapid scanning optical delay line.
9.6.Fourierdomain OCT.
9.7.Doppler OCT.
9.8.Group velocity dispersion.
9.9.Monte Carlo modeling of OCT.
9.10.References.
9.11.Further readings.
9.12.Problems.
10. MUELLER OPTICAL COHERENCE TOMOGRAPHY.
10.1.Introduction.
10.2.Mueller calculus versus Jones calculus.
10.3.Polarization state.
10.4.Stokes vector.
10.5.Mueller matrix.
10.6.Mueller matrices for a rotator, a polarizer, and a retarder.
10.7.Measurement of Mueller matrix.
10.8.Jones vector.
10.9.Jones matrix.
10.10.Jones matrices for a rotator, a polarizer, and a retarder.
10.11.Eigenvectors and eigenvalues of Jones matrix.
10.12.Conversion from Jones calculus to Mueller calculus.
10.13.Degree of polarization in OCT.
10.14.Serial Mueller OCT.
10.15.Parallel Mueller OCT.
10.16.References.
10.17.Further readings.
10.18.Problems.
11. DIFFUSE OPTICAL TOMOGRAPHY.
11.1.Introduction.
11.2.Modes of diffuse optical tomography.
11.3.Timedomain system.
11.4.Directcurrent system.
11.5.Frequencydomain system.
11.6.Frequencydomain theory: basics.
11.7.Frequencydomain theory: linear image reconstruction.
11.8.Frequencydomain theory: general image reconstruction.
11.9.Appendix 11.A. ART and SIRT.
11.10.References.
11.11.Further readings.
11.12.Problems.
12. PHOTOACOUSTIC TOMOGRAPHY.
12.1.Introduction.
12.2.Motivation for photoacoustic tomography.
12.3.Initial photoacoustic pressure.
12.4.General photoacoustic equation.
12.5.General forward solution.
12.6.Deltapulse excitation of a slab.
12.7.Deltapulse excitation of a sphere.
12.8.Finiteduration pulse excitation of a thin slab.
12.9.Finiteduration pulse excitation of a small sphere.
12.10.Darkfield confocal photoacoustic microscopy.
12.11.Synthetic aperture image reconstruction.
12.12.General image reconstruction.
12.13.Appendix 12.A. Derivation of acoustic wave equation.
12.14.Appendix 12.B. Green's function approach.
12.15.References.
12.16.Further readings.
12.17.Problems.
13. ULTRASOUNDMODULATED OPTICAL TOMOGRAPHY.
13.1.Introduction.
13.2.Mechanisms of ultrasonic modulation of coherent light.
13.3.Timeresolved frequencyswept UOT.
13.4.Frequencyswept UOT with parallelspeckle detection.
13.5.Ultrasonically modulated virtual optical source.
13.6.Reconstructionbased UOT.
13.7.UOT with FabryPerot interferometry.
Problems.
Reading.
Furhter Reading.
APPENDIX A. DEFINITIONS OF OPTICAL PROPERTIES.
APPENDIX B. List of Acronyms.
Index.
HSINI WU, PhD, is Professor of Biomedical Engineering at Texas A&M University. He has published more than fifty peerreviewed journal articles. Dr. Wu was a senior Fulbright scholar and is listed in Outstanding Educators of America. He serves on the Editorial Advisory Board of Biocomplexity and the Editorial Board of BioMedical Engineering OnLine.