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The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition

ISBN: 978-0-471-97550-2
328 pages
August 1997
The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition (0471975508) cover image
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
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Clinical Trials.

Allocating Patients to Treatments.

Measurement of Treatment Difference.

The Design of a Sequential Trial Using the Boundaries Approach.

The Analysis of a Sequential Trial.

Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.

Prognostic Factors.

The Comparison of More than Two Treatments.

Implementation of Sequential Methods: Some Examples.

References.

Appendix.

Index.
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"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)
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