While most books on evidence-based medicine deal with the interpretation of diagnostic test results, 'The Evidence Base of Clinical Diagnosis' addresses methods to construct the design itself. The book presents a framework for choosing an appropriate study design, and for preparing and executing diagnostic studies. Guidelines for both original empirical studies and systematic reviews are provided, and the applicability of research results are addressed. In addition, the book covers clinical problem solving, diagnostic decision support using ICT, and implementation issues.