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Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

ISBN: 978-0-8138-1553-4
268 pages
February 2010, Wiley-Blackwell
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Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.
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Table of Contents

Chapter 1: Introduction.

Chapter 2: History, definition and diagnosis of the metabolic Syndrome.

Chapter 3: Insulin resistance in the metabolic syndrome.

Chapter 4: Is it necessary to redefine the metabolic syndrome?

Chapter 5: Is insulin resistance a disorder of the brain?

Chapter 6: Obesity.

Chapter 7: Perinatal nutrition and obesity.

Chapter 8: Essential hypertension.

Chapter 9: Dietary factors and hypertension.

Chapter 10: Is hypertension a disorder of the brain?

Chapter 11: Type 2 diabetes mellitus.

Chapter 12: Pathophysiology of type 2 diabetes mellitus with particular reference to hypothalamus.

Chapter 13: Insulin and insulin receptors in the brain and their role in the pathogenesis of obesity and type 2 diabetes mellitus.

Chapter 14: Insulin, endothelial nitric oxide and the metabolic syndrome.

Chapter 15: Obesity, type 2 diabetes mellitus and the metabolic syndrome and the gut microbiota.

Chapter 16: Is it possible that the metabolic syndrome originates in the perinatal period?

Chapter 17: Essential fatty acids: biochemistry and Physiology.

Chapter 18: Role of EFAs/PUFAs in brain growth and development and pathophysiology of the metabolic syndrome.

Chapter 19: EFAs/PUFAs and their metabolites in insulin resistance.

Chapter 20: EFAs/PUFAs and atherosclerosis.

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Author Information

Undurti N. Das, M.D. is the Chairman and Research Director of UND Life Sciences, USA and Ramalingaswami Fellow of the Department of Biotechnology, India. Dr Das is also the Editor-in-Chief of the journal Lipids in Health and Disease. He has published more than 400 international publications and has been awarded four USA patents.
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The Wiley Advantage

  • Comprehensively reviews current research on metabolic diseases
  • Discusses molecular aspects of biochemistry, physiology, and pathology of metabolism of essential fatty acids
  • Includes chapters devoted to obesity, hypertension, heart disease and certain cancers
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