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Advances in Enzymology and Related Areas of Molecular Biology, Volume 78

Eric J. Toone (Editor)
ISBN: 978-1-118-01428-8
568 pages
November 2011
Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (1118014286) cover image
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
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Contributors vii

Preface ix

Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin

Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile

Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian

Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161
Soo-Youl Kim

Transglutaminase 2 At the Crossroads between Cell Death and Survival 197
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo

Tissue Transglutaminase and Its Role in Human Cancer Progression 247
Bo Li, Richard A. Cerione, and Marc Antonyak

Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus

Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347
Zoltan Nemes

Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti

Irreversible Inhibitors of Tissue Transglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin

Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449
Marıa A. Pajares and George D. Markham

Index 523

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Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.
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