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Drug-device Combinations for Chronic Diseases

ISBN: 978-1-118-12000-2
280 pages
December 2015
Drug-device Combinations for Chronic Diseases (1118120000) cover image

Description

This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice.

The book:
  • Discusses where drugs and devices work, where they fail, and when they need to work with each other
  • Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions
  • Covers  how a drug-device combination product is developed, tested, and regulated
  • Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
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Table of Contents

FOREWORD vii

PREFACE ix

PART I BACKGROUNDS 1

1 Addressing Medical Device Challenges with Drug–Device Combinations 3

2 Historical Survey of Drug Delivery Devices 39

3 Development of Combination Product Drug Delivery Systems 66

4 Drug–Material Interactions, Materials Selection, and Manufacturing Methods 89

PART II PRODUCTS 117

5 Steroid-Releasing Lead 119

6 Thromboresistant Vascular Graft 142

7 Device-Enabled Drug Infusion Therapies 182

8 Promus Element Plus: A Drug-Eluting Stent 214

9 Infuse Bone Graft 241

INDEX 261

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