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Biosurfaces: A Materials Science and Engineering Perspective

ISBN: 978-1-118-29997-5
392 pages
January 2015
Biosurfaces: A Materials Science and Engineering Perspective (1118299973) cover image


Ideal as a graduate textbook, this title is aimed at helping design effective biomaterials, taking into account the complex interactions that occur at the interface when a synthetic material is inserted into a living system.  Surface reactivity, biochemistry, substrates, cleaning, preparation, and coatings are presented, with numerous case studies and applications throughout.

 Highlights include:

  • Starts with concepts and works up to real-life applications such as implantable devices, medical devices, prosthetics, and drug delivery technology
  • Addresses surface reactivity, requirements for surface coating, cleaning and preparation techniques, and characterization
  • Discusses the biological response to coatings
  • Addresses biomaterial-tissue interaction
  • Incorporates nanomechanical properties and processing strategies
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Table of Contents

Chapter 1. Introduction to Biomaterials

1.1 Introduction

1.2 Summary

Chapter 2. Tissue Interaction with Biomaterials

2.1 Introduction

2.2 Protein adsorption and Cell adhesion

2.3 Cell Migration

2.4 Controlled Cell Deposition

2.5  Extracellular Matrix

2.6 Biomineralization

Chapter 3. Host Response of Implanted Biomaterials

3.1 Immune Response to Implanted Biomaterials

3.2 Transplant Immunology

3.3 Biocomaptibility

Chapter 4. Fundamentals of Surface Modification

4.1 Introduction

4.2 Surface Properties of Biomaterials

4.3 Surface modifications

4.4 Applications

Chapter 5. Multi Length Scale Hierarchy in Natural Materials

5.1 Introduction

5.2 Multi Length-scale Hierarchy

5.3 Human Bone

5.4 Turtle shell

5.5 Wood

5.6 Silk

5.7 Nacre

5.8 Gecko-feet

5.9 Lotus Leaf

Chapter 6. Superhydrophobic Surfaces

6.1 Introduction

6.2 Surfaces and superhydrophobicity in nature

6.3 Classification of surfaces

6.4 Mechanics and nature of wetting

6.5 Fabrication of artificial superhydrophobic surfaces

6.6 Preparation of metallic superhydrophobic surfaces

6.7 Controlled wettability surfaces (CWS)

6.8 Conclusions

Chapter 7. Surface Engineering and Modification for Biomedical Applications

7.1 Corrosion of Biomaterials and Need for Surface Coating for Biomedical Applications

7.2 Surface Reactivity and Body Cell Response

7.3 Key Requirements of Surface Coating

7.4 Key Biomaterial Substrates

7.5 Surface Preparation and Cleaning Techniques

7.6 Surface Engineering and Coating Techniques

7.7 Coatings for Biomedical Applications

7.8. Biosurface Characterization

Chapter 8. Laser Engineering of Surface Structures

8.1 Introduction

8.2 Laser processing of biomaterials

8.3 Laser-based prototyping methods

8.4 Ultrafast laser pulses

8.5 Neural implants

8.6 Ophthalmic implants

8.7 Laser fabrication of cardiovascular devices

8.8 Laser-fabricated nanoscale materials

8.9 Two photon polymerization

8.10 Microneedle fabrication

8.11 Conclusions

Chapter 9. Processing and Nanomechanical Properties of Hydroxyapatite-Nanotube Biocomposite

9.1 Introduction

9.2 Processing of HA-Carbon Nanotube Composites

9.3 Fracture Toughness and Tribological Properties of HA-Carbon Nanotube Composites

9.4 Adhesion of Bone Forming Cells on HA-CNT Surface

9.5 Biomechanical Compatibility at Bone/Coated Implant Interface

9.6 HA-Boron Nitride Nano Tube (BNNT) Composites

9.7 HA-TiO2 Nanotube Composites

9.8 Summary

Chapter 10. Applications of Biomaterials

10.1 Multi-scale hierarchy in natural Bone

10.2 Coronary Stents

10.3 Medical Devices

10.4 Drug Delivery

Chapter 11. Nanosafety, Nanosocietal and Nanoethical Issues

11.1 Governmental Environment and Health Safety Organization Protocols

11.2 Related Safety Hazards

11.3 Approach to Developing Safety Protocol for Laboratory Environment

11.4 Tendency of Nanoparticles

11.5 Current Capability of Nanoparticle Filters

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Author Information

Kantesh Balani, PhD, is an Associate Professor, in the Department of Materials Science & Engineering, Indian Institute of Technology (IIT) Kanpur. He has presented over 50 lectures in the international conferences and has over 65 publications in the peer-reviewed international journals. His accolades include the 2013 P.K. Kelkar Research Fellowship.


Arvind Agarwal, PhD, is Professor of Materials Science and Engineering in the Department of Mechanical and Materials Engineering at the Florida International University (FIU), Miami, Florida, USA.   He has authored more than 200 publications, edited 7 books, and co-authored 1 book in the area of coatings and nano-biomaterials. His accolades include Fellowship of ASM International.


Vivek Verma, PhD, is an Assistant Professor in the Department of Materials Science and Engineering at Indian Institute of Technology (IIT) Kanpur. He is a recipient of the prestigious American Academy of Mechanics Founder’s prize and grant for the year 2005-06 and Shri Ram Arora Award 2011.


Roger Narayan, PhD, is Professor in the Joint Department of Biomedical Engineering at the University of North Carolina (UNC) and North Carolina State University (NCSU). He is an author of over 100 publications as well as several book chapters related to biomedical materials. His accolades include the UNC Jefferson-Pilot Fellowship in Academic Medicine.

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