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Neuroinflammation and CNS Disorders

Nicola Woodroofe (Editor), Sandra Amor (Editor)
ISBN: 978-1-118-40641-0
418 pages
June 2014
Neuroinflammation and CNS Disorders (1118406419) cover image


The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches.

The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system.

Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field. 

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Table of Contents

Chapter 1: Immune privilege of the brain
Chapter 2: Innate Immunity in the CNS – A Focus on the Myeloid Cell
Chapter 3: Adaptive Immune Responses in the CNS
Chapter 4: Ageing and the immune response in the CNS
Chapter 5: Brain repair: The role of endogenous and transplanted neural stem cells
Chapter 6: Neuroinflammation in Alzheimer’s, Parkinson’s and Huntington’s Diseases
Chapter 7: CNS Infections
Chapter 8: Neuroimmunology of Amyotrophic Lateral Sclerosis
Chapter 9: Demyelinating Disorders of the CNS
Chapter 10: Other autoimmune disorders: Systemic Lupus Erythematosus, Primary Sjögren’s syndrome, Gluten-related Neurological Dysfunction and Paraneoplastic Neurological Syndromes
Chapter 11: Inflammation in the pathogenesis of depression
Chapter 12: Immune responses in the CNS in Epilepsy
Chapter 13: Inflammatory Mediators and Dysfunction of the Neurovascular Unit following Ischaemia Reperfusion
Chapter 14: Spinal cord injury
Chapter 15: Immune Responses to Tumours in the CNS
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Instructors Resources
Wiley Instructor Companion Site
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