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Blood and Marrow Transplantation Long Term Management: Prevention and Complications

Bipin N. Savani (Editor)
ISBN: 978-1-118-47340-5
414 pages
December 2013, Wiley-Blackwell
Blood and Marrow Transplantation Long Term Management: Prevention and Complications (111847340X) cover image

Currently more than 100,000 patients undergo blood and marrow transplantation (BMT) annually worldwide, a number which is steadily increasing. Long-term survival after BMT has improved significantly since its inception over 40 years ago, due to improved supportive care and early recognition of long-term complications. With broadening indications, more options for BMT, and improvement in survival, by 2020 there may be up to a million long-term survivors after BMT globally.

Higher than average rates of second malignancies and cardiopulmonary, infectious, endocrine, and renal diseases, and bone loss or avascular necrosis amongst this population suggest that the rapidly swelling ranks of BMT survivors require more frequent screening and earlier interventions than the general population.

The purpose of Blood and Marrow Transplantation Long-Term Management is to describe practical approaches to screening for and managing these late effects, with the goal of reducing preventable morbidity and mortality associated with BMT.

This unique new book is the first to address the needs of the increasing population of long-term survivors after stem cell transplantation, making it a must-have resource for all oncologists, hematologists, and primary care physicians involved in the long-term management and care of BMT patients.

Titles of related interest

Thomas’ Hematopoietic Cell Transplantation, 4th edition
Appelbaum, ISBN 9781405153485

Practical Stem Cell Transplantation
Cant, ISBN 9781405134019

Mollison’s Blood Transfusion in Clinical Medicine, 12th edition
Klein, ISBN 9781405199407

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Foreword by John Barrett vii

Foreword by Stephanie J Lee viii

Foreword by John Goldman ix

List of Contributors x

Section 1 Late effects concepts 1

1 Introduction 3
Bipin N Savani

2 Overview: transplant data and increasing numbers of long-term survivors 7
Jakob R Passweg and Helen Baldomero

3 Long-term transplant clinic setup 11
André Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovó

4 Late effects after allogeneic hematopoietic stem cell transplantation 21
Shahrukh Hashmi and Mark R Litzow

5 Late effects after autologous hematopoietic stem cell transplantation 31
Sairah Ahmed and Yago Nieto

6 Graft-versus-host disease and late effects after hematopoetic stem cell transplantation 43
Gérard Socié

7 Prominent role of allied health professionals (nurse practitioners, physician assistants, others) in long-term follow-up after hematopoietic stem cell transplantation 52
Catherine E Lucid

Section 2 Management, 55

8 Screening and prevention guidelines for hematopoietic cell transplant survivors 57
Navneet S Majhail and J Douglas Rizzo

9 Secondary malignancies: prevalence, screening, prevention, and management guidelines 65
Paolo F Caimi and Hillard M Lazarus

10 Cutaneous chronic graft-versus-host disease 77
Attilio Olivieri, Daniela Massi, Andrea Bacigalupo, and Anna Campanati

11 Anti-infective prophylaxis, immunization and prevention of recurrent infectious complications in long-term survivors 106
John P Galvin and Jayesh Mehta

12 Seasonal virus infections: prevention and management guidelines 116
Gaurav Trikha and John R Wingard

13 Exposure to family members: infections and recent live vaccinations 130
Brian G Engelhardt and James E Crowe, Jr

14 Late pulmonary complications after allogeneic hematopietic stem cell transplantion: bronchiolitis
obliterans syndrome (BOS) and organizing pneumonia (OP) 141
Lee Gazourian, Gerald L Weinhouse, Joseph H Antin, and Vincent T Ho

15 Post-transplantation bone disease: prevalence, monitoring, prevention, and management guidelines 151
Kathryn Dahir, Brandon Perry, and Shubhada Jagasia

16 Ocular complications: prevalence, monitoring, prevention, and management guidelines 162
André Tichelli and Alicia Rovó

17 Oral complications in hematopoietic stem cell transplantation survivorship 172
Sharon Elad, Corey Cutler, and Nathaniel Treister

18 Sexual dysfunction in long-term survivors: monitoring and management 183
Andrea L Utz and Shubhada Jagasia

19 Fertility issues, contraception, and pregnancy outcome in long-term survivors 193
Alicia Rovó, Nina Salooja, Carl P Schwarze, Joerg P Halter, and André Tichelli

20 Follow-up of children after hematopoietic stem cell transplantation: growth and development 203
Kristina K Hardy, David A Jacobsohn, and Evelio Perez-Albuerne

21 Posttransplant diabetes mellitus: monitoring, prevention, and management guidelines 215
Prathima Jasti, Shichun Bao, and Shubhada Jagasia

22 Thyroid disease: monitoring and management guidelines 225
M Kathleen Figaro, Cheryl A Fassler, Shubhada Jagasia, and Vipul T Lakhani

23 Special issues related to female long-term survivors 233
Melissa A Merideth, Kristin Clay Chabarria, Tajana Klepac Pulanic, and Pamela Stratton

24 Cardiac and vascular complications in long-term survivors after hematopoietic stem cell transplantation 244
Alicia Rovó and André Tichelli

25 Hyperlipidemia: prevalence, monitoring, management, interactions with immunosuppressive agents, and follow-up 258
Dara L Eckerle Mize, Shubhada Jagasia, and Jeffrey B Boord

26 Hypertension management in long-term survivors 269
Imad Abboud

27 Gastrointestinal complications of hematopoietic cell transplantation 276
Preet Bagi, Niharika Samala, Steven Pavletic, and Theo Heller

28 Hepatic complications of hematopoietic stem cell transplantation 286
Niharika Samala, Preet Bagi, Theo Heller, and Steven Pavletic

29 Monitoring and management of hepatitis B, hepatitis C, and HIV infection before and after transplantation 294
Keith Luckett and Stephen Dummer

30 Prevention and management of renal complications in long-term survivors 304
Michael Dickenmann and Joerg P Halter

31 Immunosuppressive agents and monitoring in long-term survivors 314
Paul Shaughnessy and Helen Leather

Section 3 Supportive care for long-term survivors after HSCT 321

32 Nutritional assessments and nutritional supplementation for long-term transplant survivors: multivitamins, vitamin D, calcium, antioxidants, and minerals 323
Lauren Zatarain, LaQuisa Hill, Daniel R Thomas, and Stacey A Goodman

33 Daily routines and guidelines: driving, infection isolation, masks, food/diet, activities, exercise, pets, sun exposures, and others 332
Angela M Woods

34 Caregivers of long-term survivors 340
Elizabeth Wulff-Burchfield

35 Health-related quality of life in adult and pediatric survivors of hematopoietic stem cell transplantation 345
Margaret Bevans and Lori Wiener

36 Prevalent psychosocial adjustment issues and solutions: lifestyle and social challenges 368
Katrina M Stokes

37 A patient’s perspective: concepts of long-term survivor support groups and their roles 376
Michael W Brown

APPENDIX 1 NMDP/Be The Match posttransplant guidelines resources 379
Darlene Haven

APPENDIX 2 Long-term follow-up calendar 381
André Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovó

APPENDIX 3 Commonly used transplant-related medications in long-term survivors 385
Melissa Logue

Index, 387

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Edited by Bipin N Savani Professor of Medicine, Director, Long Term Transplant Clinic, Hematology and Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, TN, USA
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