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Liposomes in Nanomedicine

ISBN: 978-1-118-54915-5
December 2012, Wiley-Blackwell

Liposomes are synthetic vesicles consisting of one or more phospholipid bilayers, able to accommodate water- and lipid-soluble molecules. They are used as a delivery system for drugs, genes and vaccines in therapeutics.

This collection of reviews and laboratory protocols provides the reader with an excellent introduction to some of the many ways in which liposomes can be labeled and used in both diagnostic and therapeutic applications. Diagnostic uses include attachment of radiolabels to track nanometer-sized liposomes in the body in a quantitative fashion using PET or SPECT imaging. The ability to track the uptake of liposomes in humans and research animals on a whole-body basis provides an excellent tool for developing liposome-based drug delivery agents. The attachment of therapeutic molecules to liposomes also has great promise in cancer therapy. In addition, recent developments in the use of liposomes carrying therapeutic radionuclides for cancer therapy will be reviewed. A laboratory protocol is also provided to illustrate how liposomes are routinely used to transfect (deliver) DNA into cells.

This e-book is a curated collection from eLS, WIREs, and Current Protocols on the topic of liposomes in nanomedicine. It is a great introduction to the field for students or interdisciplinary collaborators.

Table of Contents:

Introduction

Liposomes
eLS
Gregory Gregoriadis, Yvonne Perrie

Techniques & Applications

Topical and mucosal liposomes for vaccine delivery
WIREs Nanomedicine and Nanobiotechnology
Eder Lilia Romero, Maria Jose Morilla

Radioactive liposomes
WIREs Nanomedicine and Nanobiotechnology
William Thomas Phillips, Beth Ann Goins, Ande Bao

ATP-loaded liposomes for treatment of myocardial ischemia
WIREs Nanomedicine and Nanobiotechnology
William C. Hartner, Daya D. Verma, Tatyana S. Levchenko, Eugene A. Bernstein, Vladimir P. Torchilin

Magnetoliposomes as magnetic resonance imaging contrast agents
WIREs Nanomedicine and Nanobiotechnology
Stefaan J. Soenen, Greetje Vande Velde, Ashwini Ketkar ]Atre, Uwe Himmelreich, Marcel De Cuyper

Methods

Gene Delivery Using Helper Virus-Free HSV-1 Amplicon Vectors
Current Protocols in Neuroscience
Andrea S. Laimbacher, Cornel Fraefel

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