Chemistry of Metalloproteins: Problems and Solutions in Bioinorganic Chemistry
Addresses the full gamut of questions in metalloprotein science
Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry.
Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers:
- Alkali and alkaline earth cations
- Copper proteins
- Iron proteins
- Vitamin B12
Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics.
Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine.
Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
1 Introduction 1
Proteins: Formation, Structures, and Metalloproteins, 4
2 Alkali and Alkaline Earth Cations 31
3 Nonredox Metalloenzymes 71
Carbonic Anhydrase, 84
Alcohol Dehydrogenase, 88
4 Copper Proteins 95
Electronic Spectra of Copper Ions, 96
ESR Spectra of Copper Ions, 105
Copper Proteins, 117
Azurin and Stellacyanin, 127
Superoxide Dismutase, 131
Ascorbic Oxidase, 139
5 Iron Proteins 147
Electronic Spectra of Iron Ions, 148
Mössbauer Spectroscopy of Iron Ions, 155
ESR Spectra of Iron (III), 161
Iron Bioavailability, 166
Iron Storage and Transfer Proteins, 184
Dioxygenase Iron Proteins, 195
Iron–Sulfur Proteins, 207
2Fe–2S Ferredoxins, 212
4Fe–4S Ferredoxins, 221
Binuclear Iron Proteins, 251
Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260
Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267
Myoglobin and Hemoglobin, 275
Cytochrome C, 298
Electron Transfer in Porphyrins and Metalloporphyrins, 301
Cytochrome P-450, 322
Electronic Spectra of Hemoproteins, 327
ESR Spectra of Hemoproteins, 362
6 Vitamin B12 393
7 Chlorophyll 407
JOSEPH J. STEPHANOS, PHD, is Associate Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at Menofia University. His research examines metalloprotein chemistry, ligand-binding, and coordination chemistry of biologically active compounds.
ANTHONY W. ADDISON, PHD, is Professor of Inorganic Chemistry at Drexel University. His research focuses on bioinorganic chemistry; chemistry of dioxygen- and NO-binding metalloproteins; and the design, synthesis, and properties of novel chelating agents and macrocyclic and oligonuclear metal complexes. His numerous research articles and conference presentations have earned over 8,000 citations and a Hirsch Index of 37.