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Developmental Neuropathology

ISBN: 978-1-119-01308-2
528 pages
May 2018, Wiley-Blackwell
Developmental Neuropathology (1119013089) cover image

Description

A definitive, clinically oriented guide to the pathology of genetics of developmental neuropathology

Developmental neuropathology relates to the wide range of disorders affecting the developing brain or pre- and post-natal life, with emphasis on the genetic and molecular mechanisms involved. This book provides a practical guide to diagnosing and understanding these disorders affecting this vulnerable population and potentially stimulates further advances in this exciting area. It also addresses the controversies in inflicted head injury in infants.

The fourth major title to be approved by the International Society of Neuropathology (ISN), Developmental Neuropathology offers in-depth chapter coverage of brain development; chromosomal changes; malformations; secondary malformations and destructive pathologies; developmental vascular disorders; acquired metabolic and exogenous toxins; metabolic disorders; Rett syndrome and autism; and infectious diseases. The text provides:

  • Clinical, disease-oriented approach to the pathology and genetics developmental neuropathology
  • Fuses classical and contemporary investigative approaches
  • Includes genetic and molecular biological pathogeneses
  • Fully illustrated
  • Approved and endorsed by International Society of Neuropathology

Developmental Neuropathology is the perfect book for practicing neuropathologists, pediatric pathologists, general pathologists, neurologists, and geneticists in deciphering the pathology and pathogenesis of these complex disorders affecting the nervous system of the embryo, fetus, and child.

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Table of Contents

List of contributors

Introduction

Chapter 1: CNS Manifestations of Chromosomal Change

Chapter 2: Neural tube defects

Chapter 3: MIDLINE  PATTERNING  DEFECTS

Chapter 4: MICROCEPHALY

Chapter 5: Hemimegalencephaly and Dysplastic Megalencephaly

Chapter 6: Lissencephaly, Type I

Chapter 7: Lissencephaly, Type II (Cobblestone Lissencephaly)

Chapter 8: Polymicrogyria

Chapter 9: Cerebral Heterotopia

Chapter 10: Hippocampal sclerosis and granule cell dysplasia, and cortical dysplasia

Chapter 11: Tuberous Sclerosis Complex

Chapter 12: Chiari Malformations

Chapter 13: Dandy-Walker Malformation, Mega-Cisterna Magna, and Blake's Pouch Cyst

Chapter 14: Joubert Syndrome

Chapter 15: Cerebellar Heterotopia and Dysplasia

Chapter 16: Brainstem Malformations

Chapter 17: SPINAL CORD LESIONS

Chapter 18: HYDROCEPHALUS

Chapter 19: Antenatal Disruptive Lesions

Chapter 20: Hemorrhagic Lesions

Chapter 21: White Matter Lesions in the Perinatal Period

Chapter 22: Gray Matter Lesions

Chapter 23: Pediatric Head Injury

Chapter 24: Pediatric Vascular Malformations

Chapter 25: Sudden Infant Death Syndrome

Chapter 26: Kernicterus

Chapter 27: Lesions Induced by Toxins

Chapter 28: Disorders of Carbohydrate Metabolism

Chapter 29: Sphingolipidoses and related disorders 

Chapter 30: The Neuronal Ceroid-Lipofuscinoses

Chapter 31: Peroxisomal Disorders

Chapter 32: Mitochondrial Disorders

Chapter 33: DISORDERS OF AMINO ACID METABOLISM AND CANAVAN DISEASE

Chapter 34: Pelizaeus-Merzbacher Disease

Chapter 35: Cockayne Syndrome

Chapter 36: VANISHING WHITE MATTER DISEASE

Chapter 37: Alexander Disease

Chapter 38: Pathology and Genetics of Neuroaxonal Dystrophy/ Neurodegeneration with Brain Iron Accumulation

Chapter 39: Spinal Muscular Atrophy

Chapter 40: Autism Spectrum Disorders

Chapter 41: Intrauterine Infections

Chapter 42: Perinatal and Postnatal Infections

Chapter 43: Rasmussen Encephalitis

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