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Schiff's Diseases of the Liver, 12th Edition

ISBN: 978-1-119-25122-4
1232 pages
November 2017, Wiley-Blackwell


The most important and reliable resource for treating diseases of the liver

For more than 55 years, "Schiff" has been acclaimed as the most outstanding liver book in the world.  This new 12th edition brings the field completely up to date and includes a companion website that features a wide-variety of accessory materials. The text is evidence-based to offer hepatologists and gastroenterologists treating patients with liver disease a comprehensive and essential resource. The text highlights clinical practice and covers anatomy, pathology, testing, imaging, and the effects of liver disease on other organs. The book is written in clear and accessible terms and key features include:

  • Treatment guidelines and management algorithms for every disease
  • Full-color attractive design throughout the text
  • Informative section overviews for each section
  • Concise key concepts box in every chapter
  • A full liver transplant section

This 12th edition is thoroughly revised with the latest clinical information. The new edition offers:

  • Information on acute and chronic liver failure and infections in cirrhosis
  • Over 100 MCQs
  • Downloads for Powerpoint™ making the content ideal for presentations

Schiff's Diseases of the Liver is designed to be a first-stop reference for dealing with today’s demanding clinical situations.

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Table of Contents




About the CompanionWebsite

Part I Overview: Clinical Fundamentals of Hepatology

1 History Taking and Physical Examination for the Patient with Liver Disease
Esperance A. Schaefer and Lawrence S. Friedman

2 Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy
Michael P. Curry and Lennox J. Jeffers

3 Noninvasive and Invasive Imaging of the Liver and Biliary Tract
Koushik K. Das, Matthew A.Morgan, and Gregory G. Ginsberg

Part II General Considerations

4 Physioanatomic Considerations
Ian R. Wanless

5 Bilirubin Metabolism and Jaundice
Allan W. Wolkoff and Paul D. Berk

6 Hepatic Histopathology
Zachary D. Goodman

7 Mechanisms of Liver Injury
Harmeet Malhi and Gregory J. Gores

8 Hepatic Manifestations of Systemic Disorders
Stuart C. Gordon and Humberto C. Gonzalez

9 The Liver in Pregnancy
Nancy Reau and Yannick Bacq

Part III Consequences of Liver Disease

10 Hepatic Fibrosis
Scott L. Friedman

11 Preoperative Evaluation of the Patient with Liver Disease
Patrick S. Kamath and Mark T. Keegan

12 Management of Portal Hypertension
Guadalupe Garcia-Tsao and Juan G. Abraldes

13 Renal Complications of Liver Disease and the Hepatorenal Syndrome, 33
Xingxing S. Cheng and W. Ray Kim

14 Pulmonary Manifestations of Liver Disease
Michael B. Fallon and Anil Seetharam

15 Ascites and Spontaneous Bacterial Peritonitis
Vicente Arroyo and Javier Fern´andez

16 Hepatic Encephalopathy
Chathur Acharya and Jasmohan S. Bajaj

17 Acute Liver Failure
Robert J. Fontana and Khurram Bari

18 Acute-on-Chronic Liver Failure
Florence Wong

19 Malnutrition and Liver Disease
Craig McClain, Irina Kirpich, and Laura Smart

Part IV Cholestatic Disorders

20 Primary Sclerosing Cholangitis
John M. Vierling

21 Primary Biliary Cholangitis
Cynthia Levy, Andres F. Carrion, and Marlyn J. Mayo

22 Autoimmune Hepatitis
Gideon M. Hirschfield and Gwilym J. Webb

Part V Viral Hepatitis

23 Hepatitis A and E
Kenneth E. Sherman and Shyam Kottilil

24 Hepatitis B and D
Marc G. Ghany and Naveen Gara

25 Hepatitis C
Michael W. Fried, Jama M. Darling, and Stanley M. Lemon

Part VI Alcohol- and Drug-induced Liver Disease

26 Alcoholic Liver Disease
Mack C. Mitchell and Gyongyi Szabo

27 Drug-induced Hepatotoxicity, 740
Dominique Larrey, Jose Ursic-Bedoya, and Lucy Meunier

28 Mechanisms of Drug-induced Liver Injury
Paul B. Watkins and Merrie Mosedale

Part VII Genetic and Metabolic Disease

29 Wilson Disease
Michael L. Schilsky and Aftab Ala

30 Hemochromatosis and Iron Storage Disorders
Kris V. Kowdley and Priya Handa

31 Alpha-1 Antitrypsin Deficiency
David H. Perlmutter

32 Nonalcoholic Fatty Liver Disease
Curtis K. Argo, Zachary H. Henry, and Stephen H. Caldwell

Part VIII Vascular Diseases of the Liver

33 Vascular Liver Disease
Dominique-Charles Valla

34 The Liver in Circulatory Failure
Santiago J. Munoz, Hanisha R. Manickavasagan, and Idean Amirjazil

Part IX Benign and Malignant Tumors; Cystic Disorders

35 Benign Tumors, Nodules, and Cystic Diseases of the Liver
Julien Calderaro and Jessica Zucman-Rossi

36 Hepatocellular Carcinoma
Maddie Kubiliun and Jorge A. Marrero

37 Surgical Options in Liver Cancers
Garrett R. Roll and John Paul Roberts

Part X Infectious and Granulomatous Disease

38 Amoebic and Pyogenic Liver Abscesses
Marco A. Olivera-Mart´ýnez and David Kershenobich

39 Parasitic Diseases
Michael A. Dunn

40 Granulomas of the Liver
James H. Lewis

Part XI Elements of Liver Transplantation

41 Selection of Candidates and Timing of Liver Transplantation
Meaghan Phipps, Alyson N. Fox, and Robert S. Brown Jr.

42 Immunosuppression: The Global Picture
Caroline C. Jadlowiec, Timucin Taner, and Russell H. Wiesner

43 The First Six Months Following Liver Transplantation
K. Rajender Reddy and Manuel Mendizabal

44 Long-term Management of the Liver Transplant Patient
Timothy M. McCashland

45 The Liver Transplant Procedure
Bijan Eghtesad, Koji Hashimoto, and John Fung

46 Recurrent Disease Following Liver Transplantation
Haripriya Maddur and Josh Levitsky

47 The Role of Retransplantation
Peter L. Abt and Kim M. Olthoff

48 Controversies in Liver Transplantation
James F. Trotter


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Author Information

About the Editors
MD, MACP, FRCP, MACG, FAASLD is Professor of Medicine, University of Miami Miller School of Medicine, and Director, Schiff Center for Liver Diseases, Miami, USA.

WILLIS C. MADDREY MD, MACP, FRCP, FAASLD is Professor of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

K. RAJENDER REDDY MD, FAASLD is Ruimy Family President's Distinguished Professor of Medicine, Director of Hepatology, and Medical Director of Liver Transplantation, University of Pennsylvania, Philadelphia, USA.

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