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Medicinal Natural Products: A Biosynthetic Approach, 3rd Edition

ISBN: 978-1-119-96457-5
550 pages
September 2011
Medicinal Natural Products: A Biosynthetic Approach, 3rd Edition (1119964571) cover image
Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:

  • a comprehensive treatment of plant, microbial, and animal natural products in one volume
  • extensive use of chemical schemes with annotated mechanistic explanations
  • cross-referencing to emphasize links and similarities
  • boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

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1. ABOUT THIS BOOK, AND HOW TO USE IT.

The Subject.

The Aim.

The Approach.

The Topics.

The Figures.

Further Reading.

What to Study.

What to Learn.

Nomenclature.

Conventions Regarding Acids, Bases, and Ions.

Some Common Abbreviations.

Further Reading.

2. SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION MECHANISMS.

Primary and Secondary Metabolism.

The Building Blocks.

The Construction Mechanisms.

Alkylation Reactions: Nucleophilic Substitution.

Dehydrogenases.

Oxidases.

Monooxygenases.

Dioxygenases.

Amine Oxidases.

Baeyer-Villiger Monooxygenases.

Some Vitamins Associated with the Construction Mechanisms.

Elucidating Biosynthetic Pathways.

Further Reading.

3. THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES.

Fatty Acid Synthase: Saturated Fatty Acids.

Unsaturated Fatty Acids.

Uncommon Fatty Acids.

Prostaglandins.

Thromboxanes.

Leukotrienes.

Polyketide Synthases: Generalities.

Polyketide Synthases: Macrolides.

Macrolide Antibiotics, Erythromycins, Oleandomycin and Spiramycin, Tylosin, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Rifamycins.

Polyketide Synthases: Linear Polyketides and Polyethers.

Diels-Alder Cyclizations.

Polyketide Synthases: Aromatics.

Senna, Hypericum / St John?s Wort, Mycophenolic acid, Khellin and Cromoglicate, Griseofulvin.

Poison Ivy and Poison Oak, Cannabis, Aflatoxins, Tetracyclines, Anthracycline Antibiotics.

Further Reading.

4. THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS.

Aromatic Amino Acids and Simple Benzoic Acids.

Phenylpropanoids.

Cinnamic Acids and Esters.

Lignans and Lignin.

Phenylpropenes.

Benzoic Acids from C6C3 Compounds.

Coumarins.

Aromatic Polyketides.

Styrylpyrones, Diarylheptanoids.

Flavonoids and Stilbenes.

Flavonolignans.

Isoflavonoids.

Terpenoid Quinones.

Further Reading.

5. THE MEVALONATE AND METHYLERYTHRITOL PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS.

Mevalonic Acid and Methylerythritol Phosphate.

Hemiterpenes.

Monoterpenes.

Irregular Monoterpenes.

Iridoids.

Sesquiterpenes.

Artemisinin, Gossypol, Trichothecenes.

Diterpenes.

Sesterterpenes.

Triterpenes.

Steroids.

Stereochemistry and Nomenclature.

Cholesterol.

Phytosterols.

Vitamin D.

Steroidal Saponins.

Cardioactive Glycosides.

Bile Acids.

Adrenocortical Hormones/Corticosteroids.

Semi-Synthesis of Corticosteroids.

Progestogens.

Oestrogens.

Androgens.

Tetraterpenes.

Higher Terpenoids.

Further Reading.

6. ALKALOIDS.

Alkaloids Derived from Ornithine.

Alkaloids Derived from Lysine.

Alkaloids Derived from Nicotinic Acid.

Alkaloids Derived from Tyrosine.

Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids.

Modified Benzyltetrahydroisoquinoline Alkaloids.

Phenethylisoquinoline Alkaloids.

Terpenoid Tetrahydroisoquinoline Alkaloids.

Amaryllidaceae Alkaloids.

Alkaloids Derived from Tryptophan.

Simple Indole Alkaloids.

Simple - Carboline Alkaloids.

Terpenoid Indole Alkaloids.

Quinoline Alkaloids.

Pyrroloindole Alkaloids.

Ergot Alkaloids.

Alkaloids Derived from Anthranilic Acid.

Alkaloids Derived From Histidine.

Alkaloids Derived by Amination Reactions.

Acetate-Derived Alkaloids.

Phenylalanine-Derived Alkaloids.

Terpenoid Alkaloids.

Steroidal Alkaloids.

Purine Alkaloids.

Further Reading.

7. PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES.

Peptides and Proteins.

Ribosomal Peptide Biosynthesis.

Peptide Hormones.

Thyroid Hormones.

Hypothalamic Hormones.

Hormone, Growth Hormone-releasing Hormone/Factor, Somatostatin.

Anterior Pituitory Hormones.

Posterior Pituitory Hormones.

Pancreatic Hormones.

Interferons.

Opioid Peptides.

Ribosomal Peptide Toxins.

Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Conotoxins, Snake Venoms, Gila Monster Venom.

Enzymes.

Nonribosomal Peptide Biosynthesis.

Bacitracins, Capreomycin, Polymyxins, Daptomycin, Cyclosporins, Vancomycin and Teicoplanin, Bleomycin, Streptogramins, Dactinomycin, Cycloserine.

Modified Peptides: Penicillins, Cephalosporins and Other ?-Lactams.

Cyanogenic Glycosides.

Glucosinolates.

Cysteine Sulphoxides.

Further Reading.

8. CARBOHYDRATES.

Monosaccharides.

Oligosaccharides.

Polysaccharides.

Aminosugars and Aminoglycosides.

Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin.

Further Reading.

Index.

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  • Rapid advances have been made in the last decade in gene isolation and genetic engineering, leading to the elaboration of many biosynthetic pathways. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these new developments and other advances in the field

See More
  • Provides a comprehensive treatment of plant, microbial, and animal natural products in one volume
  • Students’ skills in deductive reasoning are developed by emphasizing the relationships between classes of natural products rather than the more traditional descriptive approach
  • Extensive further reading suggestions at the end of each chapter
  • Boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action
  • Extensive use of chemical schemes with annotated mechanistic explanations
  • Includes cross-referencing to emphasize links and similarities

See More
"Students should be empowered for a deductive analysis of the presented substances." (Arzneimittelforschung, December 2009)

"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis." (Journal of Medicinal Chemistry, August 2009)

"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products." (Education in Chemistry, September 2009)

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