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Metabolism at a Glance, 3rd Edition

ISBN: 978-1-4051-0716-7
128 pages
January 2004, Wiley-Blackwell
Metabolism at a Glance, 3rd Edition (1405107162) cover image
Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline.

Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance.

Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted.

The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level:

1. Metabolic Channelling

2. Glucose homeostasis and Reye's Disease

3. Pentose phosphate pathway and the prodcution of NADPH

4. Tryptophan metabolism in health and disease

5. Tyrosine metabolism in health and disease

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Foreword 8

Preface 9

1 Introduction to metabolic pathways 10

2 Biosynthesis of ATP I: ATP, the molecule that powers metabolism 12

3 Biosynthesis of ATP II: mitochondrial respiratory cheln 14

4 The oxidation of cytosolic NADH: the malate/aspartate shuttle and the glycerol phosphate shuttle 16

5 Metabolism of glucose to provide energy 18

6 Metabolism of one molecule of glucose yields 31 (or should it be 38?) molecules of ATP 20

7 Metabolism of glucose to glycogen 22

8 Anaerobic metabolism of glucose and glycogen to yield energy as ATP 24

9 2,3-Blsphosphoglycerate (2,3-BPG) and the red blood cell 26

10 Metabolism of glucose to fat (trlacylglycerol) 28

11 Metabolism of glucose to fatty acids and trlacylglycerol 30

12 The pentose phosphate pathway: the production of NADPH and reduced glutathione 32

13 Tha pyruvate/malate cycle and the production of NADPH 34

14 Mammals cannot synthesize glucose from fatty acids 36

15 Metabolism of trlacylglycerol to provide energy as ATP 38

16 Glycogen metabolism I 40

17 Glycogen metabolism II 42

18 Glycogen metabolism III: regulation of glycogen breakdown 44

19 Glycogen metabolism IV: regulation of glycogen synthesis 46

20 Regulation of glycolysis: overview exemplified by glycolysis In cardiac muscle 48

21 Glycolysis and the pentose phosphate pathway collaborate In liver to make fat 50

22 Glycolysis In skeletal muscle: biochemistry of sport and exercise 52

23 Regulation of gluconeogenesis 54

24 Regulation of Krebs cycle 56

25 Regulation of fatty acid oxidation: mobilization of fatty acids from storage In adipose tissue 56

26 Fatty acid oxidation and the carnitine shuttle 60

27 The ketone bodies 62

28 Ketone body utilization 64

28 II-Oxidation of unsaturated fatty acids 66

30 Peroxisomal II-oxidation 66

31 Elongation and desaturation of fatty acids 70

32 Cholesterol, bile acids and the steroid hormones 72

33 The omlthlne cycle for the production of urea: 'the urea cycle' 74

34 Metabolic chennelllng: enzymes are organized to enable chennelling of metabolic Intermediate. 76

35 Biosynthesis of the non-essential amino acids 78

36 Catabolism of amino acids I 80

37 Catabolism of amino acids II 82

38 Metabolism of amino acids to glucose in starvatlon and during the period Immediately after refeeding 84

39 Metabolism of protein to fat 86

40 Disorders of amino acid metabolism 88

41 Phenylalanine and tyresine metabolism 90

42 Tryptophan metabolism: the biosynthesis of NAD+, serotonin and melatonin 92

43 Amino acid metabolism, folate metabolism and the 'i-carbon pool' I: purine biosynthesis 94

44 Amino acid metabolism, folate metabolism and the 'i-carbon pool' II: pyrimidine biosynthesis 96

45 Porphyrin metabolism, haem and the bile pigments 98

46 Metabolism of ethanol 100

47 Sorbitol, galactitol, glucuronate and xylltol 102

48 Fructose metabolism 104

49 Metabolic pathways in fasting liver and their disorder in Reye's syndrome 106

50 Diabetes I: insulin-stimulated glucose uptake into cells and glycogen synthesis - signal transduction 1 08

51 Diabetes II: metabolic changes in Type 1 diabetes 110

52 Diabetes III: Type 1 diabetes, Type 2 diabetes, MODY and pancreatic poeell metabolism 112

53 Diabetes IV: Type 2 diabetes and insulin resistance in muscle 114

54 Diabetes V: Type 2 diabetes and insulin resistance in adipose tissue 116

55 Diabetes VI: Type 2 diabetes and insulin resistance in liver 118

Index 121

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* a best-selling title in the at a glance series
* takes a unique and popular approach to the teaching of metabolic pathways
* new edition includes five new chapters
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On the first edition:

"...a highly comprehensive set of notes and pathway maps concentrated exclusively on metabolism. If you are after an easy going metabolism book for revision or as a good reference guide, this would be the ideal choice, as it is not too daunting to read and had plenty of well-organised pathway maps to keep you busy. This is especially useful for first year medics as part of their foundation study revision"

Leech y Gelen, University of Wales College of Medicine"


"The book is easy to follow as the salient features of each metabolic pathway are highlighted on a detailed background map. This aided the introduction of the metabolic concepts in a very well-integrated fashion. The chapters on the more medical aspects will appeal especially to medical students as they correlate neatly the basic biochemical principles with the development of some metabolic diseases such as glycogen storage diseases."

Biochemistry and Molecular Biology Education

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