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Periodontal Medicine and Systems Biology

Brian Henderson (Editor), Michael Curtis (Editor), Robert Seymour (Editor), Nikolaos Donos (Editor)
ISBN: 978-1-4051-2219-1
464 pages
July 2009, Wiley-Blackwell
Periodontal Medicine and Systems Biology (1405122196) cover image


This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.

The content is divided into five sections. The first introduces the reader to the concept of systems theory and its mathematical foundation. The second section provides the reader with a current view of periodontal medicine including the microbiology, molecular genetics, relationship to systemic disease and current and future therapies. Periodontitis is caused by members of the oral microbiota and the third section provides the reader with various views of the relationship of the microbiota to the host. The fourth section moves from the bacterium to the host and its immune responses to altered host: bacteria interactions. The final section deals specifically with bone destruction in periodontitis and brings the reader up-to-date with the current view of the control network that exists between mesenchymal cells such as osteoblasts, immune cells and osteoclast precursor cells that controls bone remodelling in health and disease.

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Table of Contents




1 Systems thinking in biology (Robert M. Seymour).

2 Metagenomics and its applications to human bacterial diseases (Julian R. Marchesi).


3 Periodontitis: a modern clinical picture (Nikos Donos and Francesco D’Aiuto).

4 Plaque microbiology in (periodontal) health and disease (Anne D. Haffajee).

5 Population molecular genetics of periodontitis (Marja L. Laine, Ubele van der Velden and Bruno G. Loos).

6 Mechanisms linking periodontitis to systemic disease (Panos N. Papapanou and Jan H. Behle).

7 The impact of diabetes-enhanced inflammation on periodontal disease and bone destruction (Dana T. Graves).


8 The microbiota of humans (Gerald W. Tannock).

9 The normal oral microbiota (William G. Wade).

10 Bacterial coaggregation and periodontitis (Paul E. Kolenbrander, Natalia I. Chalmers, Saravanan Periasamy, A.M. Ding and Shayla L. West-Barnette).

11 Dynamics of biofilm formation and relationship to periodontitis (Jonathan Pratten and Nicola Mordan).

12 Quorum sensing as a means of biofilm communication (Hanjuan Shao and Donald R. Demuth).

13 Genomics of Porphyromonas gingivalis (Keisuke Nakayama).

14 Genomics of Fusobacterium nucleatum (Vinayak Kapatral).

15 The Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans genome – annotation, analysis and metabolic reconstruction (Fares Najar, Shaoping Lin, Lin Song, Hongshing Lai, James White, Steven Kenton and Bruce A. Roe).


16 A new view of innate immunity for the twenty-first century (John Wright and Clare E. Bryant).

17 Innate immunity and homeostasis in the periodontium (Richard P. Darveau).

18 Antimicrobial host defence peptides in oral health and periodontitis (Deirdre A. Devine and Celine Cosseau).

19 Control of inflammation in periodontal disease (Hatice Hasturk, Alpdogan Kantarci and Thomas E. Van Dyke).

20 Antigen-presenting cells in chronic periodontitis (Ravi Jotwani and Christopher W. Cutler).

21 B-cell responses in periodontitis (Suzanne E. Barbour, John G. Tew and Harvey A. Schenkein).

22 T-cell responses in periodontitis (Gregory J. Seymour, Erica Gemmell and Kazuhisa Yamazaki).


23 Current paradigms of osteoblast–osteoclast interactions and bacterial pathogen-induced bone resorption (Naoyuki Takahashi, Masanori Koide, Toshihide Noguchi and Tatsuo Suda).

24 Bacterial osteolytic mediators (Brian Henderson and Sean P. Nair).

25 Immune cell involvement in periodontal bone loss (Andy Y.-T. Teng).

26 How can periodontal bone loss be stopped? (Colin R. Dunstan).


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Author Information

Brian Henderson is Professor of Cell Biology in the Division of Microbial Diseases at UCL Eastman Dental Institute, University College London.

Michael A Curtis is Professor of Microbiology and Director of the Institute of Cell and Molecular Science at Barts and The London School of Medicine and Dentistry.

Robert M Seymour is Professor in the UCL Department of Mathematics, University College London.

Professor Nikos Donos is Director of Research Strategy and Head of Periodontology at UCL Eastman Dental Institute, University College London.

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The Wiley Advantage

* Features contributions from international experts
* Includes illustrations and a colour plate section
* Enables the reader to navigate the scientific basis of periodontal medicine
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Do you think you've discovered an error in this book? Please check the list of errata below to see if we've already addressed the error. If not, please submit the error via our Errata Form. We will attempt to verify your error; if you're right, we will post a correction below.

ChapterPageDetailsDatePrint Run
v Errata
The author of chapter 13 is Koji Nakayama
March 2010
ix Errata
Keisuke Nakayama should read Koji Nakayama
March 2010
193 Errata
The author of chapter 13 is Koji Nakayama
March 2010
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