Preface..

Part 1 Investigating IBD in the 21st Century.

1 Capsule endoscopy: do we need it (Joel E D Mawdsley & Mark Appleyard).

2 Pathology reports – pitfalls for the unwary (Wilfred Weinstein).

3 Non-invasive diagnosis and assessment (Alex J Di Mambro, Ana Terlevich & Chris Probert).

4 What is the best way to image perianal Crohn’s disease (Vikram A Sahni & Alison McLean).

5 Surveillance colonoscopy in UC: alternatives and ways to improve outcome (Mark Lust & William Connell).

6 Abnormal liver tests – what should we do about them (Richard Marley & Abid Suddle).

Part 2 Medical Treatment: Making the Most of What We’ve Got.

5-ASA drugs.

7 Is monitoring necessary (Rakesh Shah & Alastair Forbes).

8 Do they have a role in Crohn’s disease (Vikrant Sibartie & Brian Feagan).

Steroids.

9 Steroids in Crohn’s: are they obsolete (David Rampton).

Antibiotics for Crohn’s disease.

10 Antibiotics: which, when and for how long (Alex Kent & Jean-Frédéric Colombel).

11 Mycobacterium avium paratuberculosis in Crohn’s disease: player or spectator (Geoff Smith & Fergus Shanahan).

Immunomodulators.

12 TPMT testing: is it essential (Azhar Ansari & Jeremy D Sanderson).

13 6-Mercaptopurine or azathioprine (Dermot McGovern & Simon Travis).

14 Thiopurines: how long should we use them for (Alexandra Daley & Marc Lémann).

15 Making the most of methotrexate (Emma Greig, John Keohane & Brian Feagan).

16 Cyclosporine: balancing risk and benefit (Helena Deeney & Barney Hawthorne).

Infliximab.

17 Contraindications – absolute or relative (Rakesh Chaudhary & Subrata Ghosh).

18 How can we prevent tuberculosis (Sasha Beresford & David Rampton).

19 Dealing with infusion reactions (Gert Van Assche, Séverine Vermeire & Paul Rutgeerts).

20 Use in ulcerative colitis (Sreedhar Subramanian & Jonathan Rhodes).

21 Infliximab and surgery: health or hazard (David Rampton).

Nutritional therapy for Crohn’s disease.

22 Nutritional therapy for Crohn’s disease: is it for adults (Donald R Duerksen & Charles N Bernstein).

Part 3 Medical Treatment: What’s Round the Corner?.

23 Trials and tribulations – interpreting clinical trials in IBD (Elizabeth Carty & David Rampton).

24 Genetics – clinical and therapeutic applications (Mark Tremelling & Miles Parkes).

25 Probiotics – separating science from snakeoil (Fergus Shanahan & John Keohane).

26 Worms (David Grunkemeier & R Balfour Sartor).

27 Smoking and nicotine – poison for Crohn’s, potion for colitis (Brian Bressler & A Hillary Steinhart).

28 Heparin (Ailsa Hart & Stuart Bloom).

29 Leukocytapheresis: filtering out the facts (Peter Irving & David Rampton).

30 Appendectomy for ulcerative colitis – a therapeutic option (Richard Makins & Graham Radford-Smith).

31 Biologic treatments in IBD (Raymond D’Souza & James Lindsay).

32 Stem cell transplantation for IBD (Paul Fortun & Christopher Hawkey).

33 Complementary and alternative therapy – the way forward or a step back (Louise Langmead & David Rampton).

Part 4 Common Clinical Challenges: Beyond the Text Book.

34 Functional problems (Eamonn Quigley).

35 Psychological stress: something to worry about (Joel E D Mawdsley & David Rampton).

36 Drugs to avoid (Paul Collins & Jonathan Rhodes).

37 NSAIDs and COX-2 selective agents: cause or cure of pain in IBD (Ingvar Bjarnason & David Scott).

38 Iron replacement – is it safe and effective (Stefanie Kulnigg & Christoph Gasche).

39 Hepatitis B and C viruses – how do they affect management of IBD (Graham R Foster & Alick N S Nkhoma).

40 Pregnancy: what drugs can we use (Thea Thomas & Elspeth Alstead).

41 How to prevent growth failure in children (Jutta Köglmeier & Nick Croft).

42 Predicting outcomes in severe UC. .

Simon Travis.

43 Refractory proctitis (Anne Ballinger & Richard Makins).

44 CMV co-infection – does it matter (Daan Hommes).

45 Treatment of oral Crohn’s disease (Carlo Nunes, Michael Escudier & Jeremy D Sanderson).

46 Pathophysiologic approach to treatment of diarrhea in Crohn’s disease (Henry J Binder).

47 Short bowel (Jeremy Nightingale).

48 Management of internal fistulae (David Rampton).

49 What is indeterminate colitis (Garret Cullen & Diarmuid O’Donoghue).

50 Pouches for indeterminate colitis (Laura Hancock & Neil Mortensen).

51 Colitis-associated cancer: what’s the risk to your patients (Jayne Eaden).

52 What to do with dysplasia, DALMs, and adenomas (Matt Rutter).

Part 5 Managing IBD Outside the Gut.

53 Pyoderma gangrenosum (Ana Paula Cunha & Fernando Tavarela Veloso).

54 Arthritides – helping the joints without harming the gut (Horace Williams & Tim Orchard).

55 Prevention and treatment of osteoporosis (Richard Makins & Juliet Compston ).

56 Sclerosing cholangitis – what to do (Sue Cullen & Roger Chapman).

57 Thromboembolic disease: an under-recognized complication (Peter Irving & Fergus Shanahan).

58 Pulmonary manifestations: rare but real (Peter Irving).

Part 6 Are You Sure it’s IBD?.

59 Intestinal infections: mimics and precipitants of relapse (Sunil Samuel & Yashwant Mahida).

60 Microscopic colitis (Debbie Nathan & Peter Gibson).

61 Diverticular colitis (Linmarie Ludeman & Neil A Shepherd).

Part 7 The IBD Service: Time for a Rethink?.

62 Outpatient services – do doctors still have a role (Mark Kelly & Andrew Robinson).

63 Shared care: tactical team selection (Reshma C Rakshit & John Mayberry).

64 Databases – are they worth the bother (Stephen L Grainger).

Index