Foreword.

Introduction.

1 The gene in the twenty-first century.

Choong-Chin Liew, Victor J. Dzau.

Part I: Cardiovascular single gene disorders.

2 Monogenic hypercholesterolemia.

Ruth McPherson.

3 Hypertrophic cardiomyopathy.

Ali J. Marian.

4 Dilated cardiomyopathy and other cardiomyopathies.

Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.

5 The long QT syndrome.

Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima.

Part II: Cardiovascular polygenic disorders.

6 Atherosclerosis.

Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew.

7 Heart failure.

Markus Meyer, Peter VanBuren.

8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension.

Kiat Tsong Tan, Choong-Chin Liew.

Part III: Therapies and applications.

9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects.

Ion S. Jovin, Frank J. Giordano.

10 Stem cell therapy for cardiovascular disease.

Emerson C. Perin, Guilherme V. Silva.

11 Pharmacogenetics and personalized medicine.

Julie A. Johnson, Issam Zineh.

12 The potential of blood-based gene profiling for disease assessment.

Steve Mohr, Choong-Chin Liew.

Index.

Colour plates