Preface, ix

List of abbreviations, xi

Part 1 Understanding evidence and pain, 1

1 Why evidence matters, 3
Andrew Moore and Sheena Derry

2 Clinical trial design for chronic pain treatments, 14
Alec B. O’Connor and Robert H. Dworkin

3 Introduction to evaluation of evidence, 31
Eija Kalso

4 Neurobiology of pain, 42
Victoria Harvey and Anthony Dickenson

5 Intractable pain and the perception of time: every patient is an anecdote, 52
David B. Morris

6 Psychology of chronic pain and evidence-based psychological interventions, 59
Christopher Eccleston

Part 2 Clinical pain syndromes: the evidence, 69

7 Chronic low back pain, 71
Maurits van Tulder and Bart Koes

8 Chronic neck pain and whiplash, 83
Allan Binder

22 Headache, 279
Peer Tfelt-Hansen

23 Chest pain syndromes, 292
Austin Leach and Michael Chester

Part 3 Cancer pain, 309

24 Oncologic therapy in cancer pain, 311
Rita Janes and Tiina Saarto

25 Cancer pain: analgesics and co-analgesics, 327
Rae Frances Bell

26 Psychologic interventions for cancer pain, 337
Francis J. Keefe, Tamara J. Somers and Amy Abernethy

27 Transcutaneous electrical nerve stimulation and acupuncture, 348
Mark I. Johnson

Part 4 Treatment modalities: the evidence, 367

28 Interventional therapies, 369
Anthony Dragovich and Steven P. Cohen

29 Spinal cord stimulation for refractory angina, 400
Mats Börjesson, Clas Mannheimer, Paulin Andréll and Bengt Linderoth

30 Rehabilitative treatment for chronic pain, 407
James P. Robinson, Raphael Leo, Joseph Wallach, Ellen McGough and Michael Schatman

31 Drug treatment of chronic pain, 424
Henry McQuay

32 Complementary therapies for pain relief, 434
Edzard Ernst

Index, 439