Preface.

1 General introduction: evaluation of diagnostic procedures (J. André Knottnerus, Frank Buntinx, and Chris van Weel).

2 The architecture of diagnostic research (R. Brian Haynes and John J. You).

3 Assessment of the accuracy of diagnostic tests: the cross-sectional study (J. André Knottnerus and Jean W. Muris).

4 Diagnostic testing and prognosis: the randomized controlled trial in test evaluation research (Jeroen G. Lijmer and Patrick M. M. Bossuyt).

5 The diagnostic before–after study to assess clinical impact (J. André Knottnerus, Geert-Jan Dinant, and Onno P. Van Schayck).

6 Designing studies to ensure that estimates of test accuracy will travel (Les M. Irwig, Patrick M. M. Bossuyt, Paul P. Glasziou, Constantine Gatsonis, and Jeroen G. Lijmer).

7 Analysis of data on the accuracy of diagnostic tests (J. Dik F. Habbema, René Eijkemans, Pieta Krijnen, and J. André Knottnerus).

8 Multivariable analysis in diagnostic accuracy studies: what are the possibilities? (Frank Buntinx, Bert Aertgeerts, Marc Aerts, Rudi Bruyninckx, J. André Knottnerus, Ann van den Bruel, and Jef van den Ende).

9 Standards for reporting on diagnostic accuracy studies (Patrick M. M. Bossuyt and Nynke Smidt).

10 Guidelines for conducting systematic reviews of studies evaluating the accuracy of diagnostic tests (Frank Buntinx, Bert Aertgeerts, and Petra Macaskill).

11 Producing and using clinical prediction rules (Tom Fahey and Johan van der Lei).

12 Clinical problem solving and diagnostic decision making: a selective review of the cognitive research literature (Alan Schwartz and Arthur S. Elstein).

13 Improving test ordering and its diagnostic cost-effectiveness in clinical practice—bridging the gap between clinical research and routine health care (Ron Winkens, Trudy van der Weijden, Hans Severens, and Geert-Jan Dinant).

14 Epilogue: overview of evaluation strategy and challenges (J. André Knottnerus, Ann van den Bruel, and Frank Buntinx).

Index.