Preface to the third edition, xiv

Classification of recommendations and levels of evidence, xvi

List of abbreviations, xvii

Part I: General concepts and critical appraisal
Salim Yusuf, Editor

1 Evidence-based decision making: patient–physician interface, 3
Philip J Devereaux, Marc Pfeffer, Salim Yusuf

2 Obtaining incremental information from diagnostic tests, 14
Raymond J Gibbons

3 Clinical trials and meta-analysis, 26
Jonathan R Emberson, Colin Baigent

4 Understanding concepts related to health economics, 38
Mark A Hlatky

5 Major vascular complications in patients undergoing non-cardiac surgery: magnitude of the problem, risk prediction, surveillance, and prevention, 47
Philip J Devereaux, Matthew Chan, John Eikelboom

6 Implementing evidence-based medicine in cardiology, 63
Brahmajee K Nallamothu, Thomas T Tsai, Jack V Tu

7 The application of evidence-based medicine to employment fitness standards: the transportation industries with special reference to aviation, 79
Michael Joy

Part II: Prevention of cardiovascular diseases
Salim Yusuf and John A Cairns, Editors

8 Global perspective on cardiovascular disease, 95
K Srinath Reddy

9 Avoidance of worldwide vascular deaths and total deaths from smoking, 111
Prabhat Jha, Prem Mony, James Moore, Witold Zatonski

10 Tobacco and cardiovascular disease: achieving smoking cessation in cardiac patients, 125
Andrew Pipe

11 Lipids and cardiovascular disease, 138
Malcolm Law

12 Use of lipid-lowering agents in the prevention of cardiovascular disease, 147
R Alan Failor, Jeffrey L Probstfi eld

13 Blood pressure and cardiovascular disease, 165
Curt D Furberg, Bruce M Psaty, Elsayed Z Soliman

14 Dysglycemia and the risk of cardiovascular events, 179
Hertzel C Gerstein, Zubin Punthakee

15 Physical activity and exercise in cardiovascular disease prevention and rehabilitation, 190
Ray W Squires

16 Psychosocial factors, 201
Annika Rosengren

17 The social determinants of cardiovascular disease, 211
Martin McKee, Clara K Chow

18 Obesity, 221
Raj S Padwal, Arya M Sharma

19 Ethnicity and cardiovascular disease, 235
Clara K Chow, Sonia S Anand, Salim Yusuf

20 Fetal origins of coronary artery disease, 258
Katherine M Morrison, Stephanie Atkinson, Koon K Teo

21 Genetics of coronary heart disease, 268
Michael S Cunnington, Bernard D Keavney

22 Molecular genetics of cardiovascular disorders, 288
Ali J Marian, Robert Roberts

23 Diet and cardiovascular disease, 304
K Srinath Reddy

24 Integrating approaches to prevention of cardiovascular disease, 328
David A Wood, Kornelia Kotseva

Part IIIa: Stable coronary artery disease
John A Cairns and Bernard J Gersh, Editors

25 Medical management of stable coronary artery disease, 345
William E Boden

26 Percutaneous intervention, 357
David A Wood, Rohit Khurana, Christopher E Buller

27 Surgical coronary artery revascularization, 379
Morgan L Brown, Thoralf M Sundt III

28 Comparisons of percutaneous coronary intervention and coronary artery bypass grafting, 392
Arashk Motiei, Thoralf M Sundt III, Charanjit S Rihal

Part IIIb: Acute coronary syndromes
John A Cairns and Bernard J Gersh, Editors

29 Non-ST segment elevation acute coronary syndromes: unstable angina and non-ST segment elevation myocardial infarction, 409
Pierre Theroux, John A Cairns

30 Early prehospital management of ST segment elevation myocardial infarction, 444
Robert C Welsh, Paul W Armstrong

31 Reperfusion therapies for ST segment elevation myocardial infarction, 456
Joseph B Muhlestein, Jeffrey L Anderson

32 Antithrombotic therapies for patients with ST segment elevation myocardial infarction, 475
Andrew J Lucking, Keith A A Fox

33 Complications after myocardial infarction, 495
Peter L Thompson

34 An integrated approach to the management of patients after the early phase of ST segment elevation myocardial infarction, 516
Pedro L Sánchez, Francisco Fernández- Avilés

Part IIIc: Arrhythmias
A John Camm and John A Cairns, Editors

35 Atrial fibrillation: rhythm and rate control therapies, 531
Irina Savelieva, Albert L Waldo, A John Camm

36 Atrial fi brillation: upstream therapies, 568
Antonios Kourliouros, Irina Savelieva, Marjan Jahangiri, A John Camm

37 Atrial fibrillation: antithrombotic therapy, 581
John A Cairns, Stuart Connolly

38 Ablation therapy for atrial fi brillation, 596
Conor D Barrett, Chi Keong Ching, Luigi Di Biase, Claude S Elayi, David J Burkhardt, Rodney Horton, Andrea Natale

39 Supraventricular tachycardia, 606
Erica D Penny-Peterson, Gerald V Naccarelli

40 Prevention and treatment of life-threatening ventricular arrhythmia and sudden death, 619
Carlos A Morillo, Adrian Baranchuk

41 Pacemaker therapy, including cardiac resynchronization therapy, 636
William D Toff, A John Camm

42 Syncope, 673
David G Benditt, Fei Lu, Scott Sakaguchi

43 Cardiopulmonary resuscitation, 692
Michael Colquhoun

44 Arrhythmias due to monogenic disorders, 706
Dawood Darbar, Prince Kannankeril, Dan M L Roden

45 Arrhythmiagenic right ventricular cardiomyopathy, 721
Deirdre Ward, Perry M Elliott

Part IIId: Specifi c cardiovascular disorders: left ventricular dysfunction
Salim Yusuf, Editor

46 Epidemiology and prevention of heart failure and management of asymptomatic left ventricular systolic dysfunction, 735
J Paul Rocchiccioli, John J V McMurray

47 Management of overt heart failure, 756
Paul J Hauptman, Karl Swedberg

48 Acute myocarditis and dilated cardiomyopathy, 784
Leslie T Cooper Jr, Oyere K Onuma

49 Management of hypertrophic cardiomyopathy, 796
Barry J Maron

50 Infective and infi ltrative cardiomyopathies, 808
Stavros Kounas, Perry M Elliott

51 Chagas’ heart disease, 823
J Antonio Marin-Neto, Anis Rassi Jr, Benedito Carlos Maciel, Marcus Vinicius Simões, André Schmidt

Part IIIe: Specifi c cardiovascular disorders: pericardial disease
Bernard J Gersh, Editor

52 Pericardial disease: an evidence-based approach to clinical management, 845
Faisal F Syed, Bongani M Mayosi

Part IIIf: Specifi c cardiovascular disorders: valvular heart disease
Bernard J Gersh, Editor

53 Rheumatic heart disease: prevention and acute treatment, 861
Bongani M Mayosi, Patrick J Commerford

54 Mitral valve disease: indications for surgery, 869
Blase A Carabello

55 Surgical indications in aortic valve disease, 878
Sunil Mankad, Heidi M Connolly, Shahbudin H Rahimtoola

56 Non-surgical aortic valve therapy: balloon valvuloplasty and transcatheter aortic valve replacement, 896
Robert H Boone, John G Webb

57 Balloon valvuloplasty: mitral valve, 913
Zoltan G Turi

58 Valve repair and choice of valve, 927
Shafie S Fazel, Tirone E David

59 Infective endocarditis, 941
Zainab Samad, Andrew Wang

60 Antithrombotic therapy after heart valve replacement, 957
Jack C J Sun, John W Eikelboom

Part IIIg: Specifi c cardiovascular disorders: other conditions
Bernard J Gersh and Salim Yusuf, Editors

61 Stroke, 971
Brian H Buck, Ashfaq Shuaib, Craig Anderson

62 Heart disease and pregnancy, 993
Rachel M Wald, Samuel C Siu

63 Adult congenital heart disease, 1006
Elisabeth Bédard, Michael A Gatzoulis

64 Venous thromboembolic disease, 1032
Lori-Ann Linkins, Clive Kearon

65 Peripheral arterial disease, 1050
Catherine McGorrian, Sonia S Anand

66 Cardiac risk in those undergoing non-cardiac surgery, 1068
Ameeth Vedre, Kim A Eagle

67 Clinical management of diseases of the aorta, 1079
Thoralf M Sundt III

68 Cardiac transplantation: indications and postoperative management, 1099
Barry Boilson, Sudhir Kushwaha

69 Renal dysfunction, 1110
Johannes F E Mann, Ernesto L Schiffrin

70 Pulmonary hypertension, 1118
Brendan P Madden

Part IV: Clinical applications
Ernest L Fallen, Editor

71 Clinical applications of external evidence, 1135
Ernest L Fallen, Salim Yusuf

72 Stable angina: choice of PCI versus CABG versus drugs, 1138
William S Weintraub

73 Non-ST segment acute coronary syndrome, 1142
David Fitchett

74 Acute ST segment elevation myocardial infarction, 1152
Ernest L Fallen

75 Secondary prevention strategies post myocardial infarction, 1157
Jacques Genest

76 Heart failure, 1164
Michael M Givertz, Garrick C Stewart

77 Atrial fibrillation, 1170
Michael Klein

78 The case for and against implantable cardioverter defibrillators in patients with coronary artery disease, 1174
Jeffrey S Healey

79 Bradyarrhythmias – choice of pacemakers, 1178
Pablo B Nery, Carlos A Morillo

80 Peripheral arterial disease with suspect coronary artery disease, 1183
Victor Aboyans, Michael H Criqui

81 Valvular heart disease: timing of surgery, 1187
Jon-David R Schwalm, Victor Chu

Index, 1191

The colour plate section can be found facing p. 941