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Bone Marrow Pathology, 4th Edition

ISBN: 978-1-4051-6825-0
640 pages
January 2010, Wiley-Blackwell
Bone Marrow Pathology, 4th Edition (1405168250) cover image
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis.

This fourth edition:

  • Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
  • Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis
  • Includes new diagnostic algorithms and summary boxes
  • Contains 550 colour illustrations including high-quality digital photomicrographs 

Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.

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Preface to the fourth edition, vi

Acknowledgements, vii

Abbreviations, viii

1 The normal bone marrow, 1

2 Special techniques applicable to bone marrow diagnosis, 54

3 Infection and reactive changes, 100

4 Acute myeloid leukaemia, mixed phenotype acute leukaemia, the myelodysplastic syndromes and histiocytic neoplasms, 166

5 Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions, 239

6 Lymphoproliferative disorders, 300

7 Plasma cell neoplasms, 421

8 Disorders of erythropoiesis, granulopoiesis and thrombopoiesis, 461

9 Miscellaneous disorders, 500

10 Metastatic tumours, 549

11 Diseases of bone, 587

Appendix, 601

Index, 611

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Barbara J. Bain, MBBS, FRACP, FRCPath
Professor of Diagnostic Haematology, St Mary's Hospital Campus of Imperial College, Faculty of Medicine, Imperial College, London and Honorary Consultant Haematologist, St Mary's Hospital, London, UK

David M. Clark, MD, MRCP(UK), FRCPath
Consultant Histopathologist, Path Links, N Lincolnshire and Goole Hospitals NHS Foundation Trust; Honorary Consultant Histopathologist, Nottingham University Hospitals, and Special Lecturer in Pathology, University of Nottingham, UK

Bridget S. Wilkins, DM, PhD, FRCPath
Consultant in Haematopathology, Guy's and St Thomas' Hospitals NHS Foundation Trust, London; Honorary Senior Lecturer in Haematopathology, King's College, London

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"This book is excellent. Haematopathology can be daunting and the study of bone marrows especially so. The authors deserve credit for producing a book that is not only easy to read and understand, but is also a compact, detailed and exhaustive guide.  I would highly recommend it to trainees and consultants in haematology and histopathology alike. Each and every department that reports bone marrows should have it in their library, preferably within easy reach." (ACP News, December 2010)

“This is one of only a few references that effortlessly integrate the entire process critical for accurate bone marrow interpretation. It is a must for practicing hematopathologists.” (Doody’s,

"Trainee medical and laboratory staff in haematology and histopathology will all derive great benefit from using this publication to aid their studies. The logical approach, concise text, and abundance of illustrations make this book an important addition to any reading list used as preparation for examinations. In short, this is a seriously good book!" (The Bulletin of the Royal College of Pathologists, July 2010)

"Bone Marrow Pathology is illustrated very well and contains clear and straightforward description of the broad spectrum of bone marrow pathology. The book is of huge value for histopathologists and hematologists practicing bone marrow diagnostics." (Hematological Oncology, February 2010)

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