Diseases of the Liver and Biliary System in Children, 3rd Edition
January 2009, Wiley-Blackwell
Diseases of the Liver and Biliary System in Children, Third Edition provides a practical approach to the diagnosis and management of paediatric liver diseases, highlighting the importance of multidisciplinary team working and holistic management of the child and family. This fully revised edition has also been updated to cover recent advances in paediatric hepatology. It includes new chapters describing the effects of liver disease in pregnancy on mother and child through to adolescence. With increasing numbers of young people surviving into adult life this edition addresses the importance of managing adolescent transition effectively.
Trainees, practising paediatric gastroenterologists and hepatologists will welcome the practical approach outlined in this text, while other healthcare professionals involved in the management of liver disease in children will find it an accessible and comprehensive reference.
1. Structure, Function and Repair.
Ulrich Baumann, Rachel Brown, Alastair Millar, Bobbie Jones, Patrick McKiernan.
Section 2: Investigating the Liver.
2. The approach to the child with liver disease: Differential diagnosis and useful investigations.
3. Interventional Radiology in the Diagnosis & Management of Liver Disease.
Section 3: Supporting the Family.
4. The Effects on Mother and Child.
Section 4: Neonatal Liver Disease.
5. The Jaundiced Baby.
6. The Acutely Ill Baby.
Section 5: Acute Liver Disease.
7. Infective disorders of the liver.
Suzanne Davison, Elizabeth Boxall.
8. Fulminant Hepatitis and Acute Liver Failure.
Estella Alonso, Rob Squires, Peter Whitington.
Section 6: Liver Disease in Older Children.
9. Auto Immune Liver Disease.
Giorgina Mieli-Vergani, Diego Vergani.
10. Drug Induced Liver Disease.
11. Congenital and Structural Abnormalities of the Liver.
Jaime Liou Wolfe, Kathleen Schwarz.
12. Non-Alcoholic Steatosis.
13. Hepatobiliary Disease in Cystic Fibrosis.
Section 7: Metabolic Liver Disease.
14. Metabolic Liver Disease in Older Children.
Anne Green, Anupam Chakrapani.
15. Disorders of Copper Metabolism.
Section 8: Management of Chronic Liver Disease.
16. Complications and Management of Chronic Liver Disease.
Section 9: The Liver and other Organs.
17. The Liver in Systemic Illness.
18. Skin Disorders in Liver Disease.
Indra van Mourik, Michelle Thomson.
19. Dental Care of Children with Liver Disease.
Marie-Therese Hosey, Victoria Clark.
Section 10: Surgical Management of Liver Disease.
20. Surgical Disorders of the Liver and Bile Ducts.
21. Primary Hepatic Tumours.
Bruce Morland, Jean De Ville.
Section 11: Transplantation.
22. Liver Transplantation.
Deirdre Kelly, A. Mayer.
23. Small Bowel and Liver Transplantation.
Section 12: The Developing World.
24. Liver Disease in the Developing World.
Anupam Sibal, S. Quak, M. Chang.
Section 13: Supporting the Family.
25. The role of the Multi Disciplinary Team.
Graham Gordon, Julie Reed, Jacqueline Blyth, Carolyn Patchell.
26. Transition to Adult Care.
Janet McDonagh, Deirdre Kelly
She was born and brought up in Calcutta, India, in the post-Raj
era while her father was working for Lipton's Tea. She spent her
early childhood in India and went to boarding school in Dublin when
she was 12 years old. She first decided to become a doctor at the
age of 8 and despite much opposition from family and nuns at her
convent school, persisted and went to Trinity College Dublin to
study medicine in 1967.
She originally planned to be a General Practitioner but in her
Senior House Officer days was encouraged to take an academic line
and apply for General Medicine rotations and take the membership
exams. She trained first in adult medicine, and then in
gastroenterology and hepatology in Dublin with Professor Donald
Weir who encouraged her to do an MD thesis on folate catabolism
with Professor John Scott, a world authority on folate
While in Dublin she had her two delightful sons while juggling
research/academic medicine/clinical practice and discovered the
joys of being a mother.
In 1982, she moved to London to work with Dame Sheila Sherlock
at the Royal Free Hospital, where she became interested in
pediatric hepatology. Dr Kelly retrained in pediatrics with
Professor Otto Wolff at Great Ormond Street and Professor John
Walker Smith at Queen Elizabeth Hospital, Hackney.
In 1987 she went to work as an Assistant Professor in Pediatric
Gastroenterology and Hepatology at the University of Nebraska in
Dr Kelly used this time to learn about caring for children
undergoing liver transplantation. Equipped with these new skills
she returned to Birmingham in 1989 to set up a National Liver Unit
to care for children with liver disease and undergoing liver
The Unit has been very successful and is one of the busiest
pediatric liver transplant programmes with survival rates of >
90%. Dr Kelly now has three other consultant colleagues and a team
of junior doctors, research fellows, specialist nurses and other
valuable members of the multidisciplinary team.
They have achieved international standards for care of children
with liver disease and liver transplantation and currently are the
only unit in the UK to provide small bowel transplantation for
They have expanded their research programme to look at mechanisms which control the development of biliary epithelial cells, the underlying mechanisms for the pathophysiology of malnutrition in children with liver disease and the natural history and management of chronic viral hepatitis in childhood. They have a major interest in the outcome and quality of life following transplantation.
- Provides a practical approach to the diagnosis and management
of paediatric liver diseases, highlighting the importance of
multidisciplinary team working and holistic management of the child
- New chapters describe the effects of liver disease from
pregnancy to adolescence to reflect the importance of managing
- In full colour, this edition summarises the advances of the
past four years.
- Will interest non-specialist paediatricians and paediatric trainees, as well as adult gastroenterologists and hepatologists.