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Allergy and Allergic Diseases, 2nd Edition

A. Barry Kay (Editor), Jean Bousquet (Editor), Patrick G. Holt (Editor), Allen P. Kaplan (Editor)
ISBN: 978-1-4443-0092-5
2184 pages
January 2009, Wiley-Blackwell
Allergy and Allergic Diseases, 2nd Edition (144430092X) cover image


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This two volume book is an outstanding reference source on all aspects of allergy and allergic diseases. Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team (A.B.Kay, Jean Bousquet, Pat Holt and Allen Kaplan) have completely revised and updated the text, from both a scientific and clinical perspective. References will continue to be added to the text until it goes to press making this the most up-to-date book available in the field.

This second edition consists of more than 1,800 pages contained within 98 chapters.

The price includes a fully searchable companion CD ROM with the complete text and over 300 images from the book in full colour.

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Table of Contents

List of Contributors ix

Foreword xvii

Preface xviii

VOLUME 1 The Scientific Basis of Allergy

Part 1 Immunology of the Allergic Response

1 Allergy and Hypersensitivity: History and Concepts 3
A. Barry Kay

2 Development of Allergy and Atopy 23
Catherine Thornton and Patrick G. Holt

3 T Cells and Cytokines in Asthma and Allergic Inflammation 48
Chris Corrigan

4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma 83
Catherine Hawrylowicz and Cezmi A. Akdis

5 IgE and IgE Receptors 103
Brian J. Sutton, Andrew J. Beavil, Rebecca L. Beavil, and James Hunt

6 Immunoglobulin Gene Organization and Expression and Regulation of IgE 119
Hannah J. Gould and David J. Fear

7 Environmental Factors in IgE Production 141
Anne Tsicopoulos, Catherine Duez, and Andrew Saxon

8 Antigen-presenting Dendritic Cells and Macrophages 166
Bart N. Lambrecht and Hamida Hammad

9 Innate Immunity in Allergic Disease 187
Ian Sabroe

10 Signal Transduction in Allergic and Inflammatory Cells 203
Rafeul Alam

Part 2 Inflammatory Cells and Mediators

11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases 217
Peter Bradding and Glenn Cruse

12 Eosinophils: Biological Properties and Role in Health and Disease 258
Simon P. Hogan, Helene F. Rosenberg, Redwan Moqbel, Simon Phipps, Paul S. Foster, Paige Lacy, A. Barry Kay, and Marc E. Rothenberg

13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases 295
Alison M. Condliffe, Andrew S. Cowburn, and Edwin R. Chilvers

14 Basophils: Biological Properties and Role in Allergic Diseases 320
Gianni Marone, Giuseppe Spadaro, and Arturo Genovese

15 Leukocyte Adhesion in Allergic Inflammation 337
Michelle J. Muessel and Andrew J. Wardlaw

16 Airway Epithelium 366
Pedro C. Avila and Robert P. Schleimer

17 Airway Vascularity in Asthma 398
John W. Wilson

18 Fibroblasts and the Extracellular Matrix 412
Lynne A. Murray, William G. Glass, Anuk M. Das, and Geoffrey J. Laurent

19 Immune Complexes and Complement: Their Role in Host Defense and in Disease 436
Michael M. Frank and C. Garren Hester

20 Bradykinin Pathways and Allergic Disease 451
Allen P. Kaplan

21 Chemokines 471
James E. Pease and Timothy J. Williams

22 Neurotrophins 494
Wolfgang A. Nockher, Sanchaita Sonar, and Harald Renz

23 Neuropeptides 511
David A. Groneberg and Axel Fischer

24 Late-phase Allergic Reactions in Humans 524
Yee-Ean Ong and A. Barry Kay

Part 3 Pharmacology

25 Antihistamines 551
F. Estelle, R. Simons, and Keith J. Simons

26 Lipid Mediators: Leukotrienes Prostanoids Lipoxins and Platelet-activating Factor 566
Sophie P. Farooque, Jonathan P. Arm, and Tak H. Lee

27 Theophylline and Isoenzyme-selective Phosphodiesterase Inhibitors 634
Mark A. Giembycz

28 Adrenergic Agonists and Antagonists 668
Tony R. Bai

29 Cholinergic Antagonists 683
Nicholas J. Gross

30 Antileukotriene Agents 694
Graeme P. Currie and Brian J. Lipworth

31 Glucocorticosteroids 715
Peter J. Barnes

32 Immunomodulating Drugs 732
Iain A.M. MacPhee

Part 4 Physiology

33 Physiologic Aspects of Asthma 749
Philip W. Ind and Neil B. Pride

34 Aerosol Delivery Systems 768
Thomas G. O’Riordan and Gerald C. Smaldone

35 Bronchial Hyperresponsiveness 783
Guy F. Joos

36 Exercise-induced Bronchoconstriction: Animal Models 794
Arthur N. Freed and Sandra D. Anderson

37 Exercise-induced Bronchoconstriction: Human Models 808
Arthur N. Freed and Sandra D. Anderson

38 Sensory and Autonomic Nervous System in Asthma and Rhinitis 823
Bradley J. Undem and Kevin Kwong

39 Mucus and Mucociliary Clearance in Asthma and Allergic Rhinitis 840
Duncan F. Rogers

40 Biology of Vascular Permeability 857
Peter Clark

41 Airway Smooth Muscle 874
Stuart J. Hirst

Part 5 Allergens

42 Biochemistry of Allergens and Recombinant Allergens 895
Rudolf Valenta

43 Host Responses to Allergens 913
Wayne R. Thomas and Belinda J. Hales

44 Allergen Extracts and Standardization 928
Ronald van Ree

45 Grass Tree and Weed Pollen 942
Jean Emberlin

46 Fungi as Allergens 963
Cathryn C. Hassett, W. Elliott Horner, Estelle Levetin, Laurianne G. Wild, W. Edward Davis, Samuel B. Lehrer, and John Lacey

47 Dust Mites and Asthma 984
Thomas A.E. Platts-Mills and Judith A. Woodfolk

48 Animal Allergens 997
Adnan Custovic and Angela Simpson

49 Airborne Allergens and Irritants in the Workplace 1017
Xaver Baur

50 Allergens from Stinging Insects: Ants Bees and Vespids 1123
Te Piao King and Rafael I. Monsalve

51 Cockroach Allergens Environmental Exposure and Asthma 1131
Martin D. Chapman and Anna Pomés

52 Food Allergens 1146
Ricki M. Helm and A. Wesley Burks

53 Latex Allergy 1164
Robyn E. O’Hehir, Michael F. Sutherland, Alexander C. Drew, and Jennifer M. Rolland

Part 6 Animal Models of Asthma

54 Primate Models of Allergic Asthma 1187
Charles G. Plopper, Suzette M. Smiley-Jewell, Lisa A. Miller, Michelle V. Fanucchi, Michael J. Evans, Alan R. Buckpitt, Mark V. Avdalovic, Laurel J. Gershwin, Jesse P. Joad, Radhika Kajekar, Shawnessy D. Larson, Kent E. Pinkerton, Laura S. Van Winkle, Edward S. Schelegle, Emily M. Pieczarka, Reen Wu, and Dallas M. Hyde

55 Airway Remodeling in Small Animal Models 1202
Clare M. Lloyd

56 Are Animal Models of Asthma Useful? 1214
Reinhard Pabst


VOLUME 2 Allergic Diseases: Etiology Diagnosis and Treatment

Part 7 Etiology and Pathology

57 Genetics of Asthma and Atopic Dermatitis 1225
Saffron A.G. Willis-Owen, Miriam F. Moffatt, and William O.C. Cookson

58 Epidemiology of Asthma Atopy and Atopic Disease 1239
Debbie L. Jarvis, Seif O. Shaheen, and Peter Burney

59 The Allergy March 1259
Ulrich Wahn

60 Outdoor Air Pollution and Allergic Airway Disease 1266
Gennaro D’Amato

61 Indoor Air Pollution 1279
Paul Harrison, Rebecca Slack, and Sanjeev Bagga

62 Molecular Immunopathology of Allergic Disease 1290
Susan Foley and Qutayba Hamid

Part 8 Diagnosis of Allergic Disease

63 Principles and Practice of Diagnosis and Treatment of Allergic Disease 1321
Anthony J. Frew and A. Barry Kay

64 Skin Testing in Diagnosis and Management of Respiratory Allergic Diseases 1335
Pascal Demoly, Anaïs Pipet, and Jean Bousquet

65 Allergy Testing in the Laboratory 1346
Steven O. Stapel and Jörg Kleine-Tebbe

66 Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air 1368
Ian D. Pavord and Dominick E. Shaw

Part 9 Allergic Rhinoconjunctivitis and Immunotherapy

67 Definition and Classification of Allergic Rhinitis and Upper Airways Diseases 1383
Wytske Fokkens and Jean Bousquet

68 Pathophysiology of Allergic Rhinitis 1402
Peter H. Howarth

69 Management and Treatment of Allergic Rhinitis 1430
Jean Bousquet and Michael A. Kaliner

70 Nasal Polyps and Rhinosinusitis 1454
Wouter Huvenne, Paul Van Cauwenberge, and Claus Bachert

71 Ocular Allergy 1482
Avinash Gurbaxani, Virginia L. Calder, and Susan Lightman

72 Mechanisms in Allergen Injection Immunotherapy 1510
Stephen J. Till and Stephen R. Durham

73 Allergen Injection Immunotherapy: Indications and Practice 1522
Hans-Jørgen Malling

74 Sublingual Immunotherapy 1543
G. Walter Canonica and Giovanni Passalacqua

75 Novel Approaches to Allergen Immunotherapy 1555
Mark Larché

Part 10 Asthma and its Treatment

76 Definition Clinical Features Investigations and Differential Diagnosis of Asthma 1567
Piero Maestrelli, Gaetano Caramori, Francesca Franco, and Leonardo M. Fabbri

77 Asthma in Infancy and Childhood 1591
John O. Warner

78 Pathogenesis of Asthma 1608
Stephen T. Holgate

79 Pathology of Asthma 1632
Peter K. Jeffery, A. Barry Kay, and Qutayba Hamid

80 Management of Chronic Asthma 1650
Peter J. Barnes

81 Anti-IgE in Persistent Severe Allergic Asthma 1661
Marc Humbert, Stephen T. Holgate, Howard Fox, and Jean Bousquet

82 Occupational Asthma 1687
Paul Cullinan and Anthony J. Newman Taylor

83 New Drugs for the Treatment of Allergy and Asthma 1712
Trevor T. Hansel, Ed Erin Onn, Min Kon, and Peter J. Barnes

Part 11 Eosinophil-associated Disease and Hypersensitivity Pneumonitis

84 Allergic Bronchopulmonary Aspergillosis 1743
André-Bernard Tonnel, Stéphanie, Pouwels-Frys, and Isabelle Tillie-Leblond

85 Extrinsic Allergic Alveolitis/Hypersensitivity Pneumonitis 1757
Michael C. Zacharisen and Jordan N. Fink

86 Pulmonary Eosinophilia 1779
Jean-François Cordier and Vincent Cottin

87 Hypereosinophilic Syndromes 1802
Hans-Uwe Simon

Part 12 Allergy and the Skin

88 Atopic Dermatitis 1813
Julia D. Proelss and Thomas Bieber

89 Contact Dermatitis 1831
David I. Orton and Carolyn M. Willis

90 Urticaria and Angioedema 1853
Allen P. Kaplan

91 Mastocytosis 1878
Nataliya M. Kushnir-Sukhov, Dean D. Metcalfe, and Jamie A. Robyn

Part 13 Anaphylaxis and Allergy to Food and Drugs

92 Anaphylaxis 1897
M. Rosario Caballero, Stephen J. Lane, and Tak H. Lee

93 Food Allergy and Eosinophilic Gastroenteropathies 1921
Scott H. Sicherer and Hugh A. Sampson

94 Drug Hypersensitivity 1943
Werner J. Pichler

95 Hypersensitivity to Aspirin and other NSAIDs 1966
Andrzej Szczeklik, Ewa NiLankowska-Mogilnicka, and Marek Sanak

96 Insect Sting Allergy 1980
Ulrich R. Müller

Part 14 Prevention of Allergic Disease

97 Prevention of Allergic Disease 1997
Susan L. Prescott and Bengt Björkstén

98 Prevalence of Atopic Disorders in a Developing World: Pitfalls and Opportunities 2020
Maria Yazdanbakhsh, Taniawati Supali, and Laura C. Rodrigues


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Author Information

A Barry Kay, National Heart and Lung Institute, London, UK

Allan P Kaplan, National Allergy and Asthma Centre, South Carolina, USA

Jean Bousquet, Hopital Arnaud dde Villeneuve, Montpellier, France

Patrick G Holt, Telethon Institute for Child Health, Perth, Australia

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The Wiley Advantage

An outstanding reference source covering all aspects of allergy and allergic diseases

  • Two volume major reference work with 98 chapters dealing with the immunologic basis of the allergic response, and then with the cells and mediators responsible for allergic inflammation.
  • Descriptions of the pharmacology and physiology of allergic diseases given, then each specific allergic disease and its management is addressed.
  • Increased coverage of drug allergens and allergic hypersensitivity reaction to drugs and the field of genetics.
  • Includes a fully searchable CD-ROM which includes the complete text 100 images from the book in full colour.
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"All allergists will benefit from owning this reference. It is an excellent source for learning or brushing up on the most recent knowledge for understanding what causes allergic diseases." (Doody's, 8 April 2011)


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