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Pediatric Hematology and Oncology: Scientific Principles and Clinical Practice

Edward Estlin (Editor), Richard Gilbertson (Editor), Rob Wynn (Editor)
ISBN: 978-1-4443-2255-2
442 pages
July 2011, Wiley-Blackwell
Pediatric Hematology and Oncology: Scientific Principles and Clinical Practice (1444322559) cover image


This new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. It is specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders.   This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children’s cancers and contains detailed tables, fact boxes and illustrations.

The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sections are then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacology and the findings of clinical trials. For each area of science covered, key original references and reviews are highlighted to direct further reading.

Diagnostic, biological, and therapeutic issues are integrated into each tumor-specific chapter, with evidence supporting the current rationales for risk stratification and the development of novel therapies. A final section then explores supportive care, palliative care, late effects considerations and psychosocial issues as relate to children’s cancer.

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Table of Contents


1 Introduction (Edward J. Estlin, Richard J. Gilbertson and Robert F. Wynn).

Part I Central Nervous System Tumors of Childhood.

2 Low- and High-Grade Glioma (Ian F. Pollack).

3 Ependymoma (Thomas E. Merchant and Richard J. Gilbertson).

4 Embryonal Tumors (Amar Gajjar and Steven C. Clifford).

5 Pediatric Spinal Cord Tumors (Annie Huang, Ute Bartels and Eric Bouffet).

6 Pediatric Craniopharyngioma, Mixed Glioneuronal Tumors, and Atypical Teratoid/Rhabdoid Tumor (Adrienne Weeks and Michael D. Taylor).

Part II Hematological Disorders.

7 Acute Lymphoblastic Leukemia (Robert F. Wynn).

8 Acute Myeloid Leukemia and Myelodysplastic Disorders (David K.H. Webb).

9 Non-Hodgkin’s Lymphoma (Angelo Rosolen and Lara Mussolin).

10 Hodgkin's Lymphoma (Wolfgang Dörffel and Dieter Körholz).

11 Histiocytic Disorders (Sheila Weitzman and R. Maarten Egeler).

Part III Solid Tumors of Childhood.

12 Neuroblastoma (Sucheta J. Vaidya and Andrew D. J. Pearson).

13 Renal Tumors (Edward J. Estlin and Norbert Graf).

14 Soft Tissue Sarcoma (Gianni Bisogno and John Anderson).

15 Bone Tumors (Richard Gorlick, Martha Perisoglou and Jeremy Whelan).

16 Hepatic Tumors (Penelope Brock, Derek J. Roebuck and Jack Plaschkes).

17 Germ Cell Tumors (James Nicholson and Roger Palmer).

18 Retinoblastoma (Edward J. Estlin, François Doz and Michael Dyer).

19 Rare Tumors (Bernadette Brennan and Charles Stiller).

Part IV Supportive Care, Long-Term Issues, and Palliative Care.

20 Supportive Care: Physical Consequences of Cancer and its Therapies (Bob Phillips and Roderick Skinner).

21 Psychosocial Needs of Children with Cancer and Their Families (Ged Lalor and Louise Talbot).

22 Late Effects in Relation to Childhood Cancer (Louise Talbot and Helen Spoudeas).

23 Palliative Care (Lynda Brook).

24 Clinical Trials Involving Children with Cancer – Organizational and Ethical Issues (Sue Ablett and Edward J. Estlin).


Colour plate.

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Author Information

Edward J. Estlin, BSc (Hons), PhD, MRCP, FRCPCH
Macmillan Consultant in Paediatric Oncology, Department of Paediatric Oncology, Royal Manchester Children’s Hospital, Manchester, UK

Richard J. Gilbertson, B.Med.Sci (Hons), MRCP, PhD
Co-Leader, Neurobiology and Brain Tumor Program; Director, Molecular Clinical Trials Core, Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA

Robert F. Wynn, BA, MD, MRCP, FRCPath
Consultant Paediatric Haematologist and Programme Director, Blood and Marrow Transplant Unit, Royal Manchester Children’s Hospital, Manchester, UK

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“It is compact, concise, and easy to read and understand, and certainly a useful addition to the field.”  (Doody's, 3 August 2012)

"However, overall, this is a useful book, probably most useful for paediatricians who may be providing shared care for paediatric oncology patients, junior doctors on haematology/oncolgy ward." (The Bulletin of the Royal College of Pathologists, 1 July 2011)

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