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Part I: Prologue:.

1. From Organ to Molecules: Steps and Consequences: Rafael Beyar.

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Part II: Cardiac Cell Development:.

2. Evolution of the Heart from Bacteria to Man: Nanette H. Bishopric.

3. The Miscommunicative Cardiac Cell: When Good Proteins Go Bad: Aldrin V. Gomes, Gayathri Venkatraman, and James D. Potter.

4. Multiple Stem Cell Populations Contribute to the Formation of the Myocardium: Leonard M. Eisenberg, Ricardo Moreno, and Roger R. Markwald.

5. Differentiation Pathways in Human Embryonic Stem Cell-Derived Cardiomyocytes: Sophie Lev, Izhak Kehat, and Lior Gepstein.

6. Functional Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes: Katya Dolnikov, Mark Shilkrut, Naama Zeevi-Levin, Asaf Danon, Sharon Gerecht-Nir, Joseph Itskovitz-Eldor, and Ofer Binah.

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Part III: Calcium Signaling:.

7. The Assembly of Calcium Release Units in Cardiac Muscle: Clara Franzini-Armstrong, Feliciano Protasi, and Pierre Tijskens.

8. Calcium Signaling in Cardiac Ventricular Myocytes: Donald M. Bers and Tao Guo.

9. Calcium Biology of the Transverse Tubules in Heart: Long-Sheng Song, Silvia Guatimosim, Leticia Gómez-Viquez, Eric A. Sobie, andrew Ziman, Hali Hartmann, and W. J. Lederer.

10. Multimodality of Ca2+ Signaling in Rat Atrial Myocytes: Martin Morad, Ashkan Javaheri, Tim Risius, and Steve Belmonte.

11. Effects of Na+-Ca2+ Exchange Expression on Excitation-Contraction Coupling in Genetically Modified Mice: Joshua I. Goldhaber, Scott A. Henderson, Hannes Reuter, Christian Pott, and Kenneth D. Philipson.

12. Mitochondrial Calcium Signaling and Energy Metabolism: My-Hanh T. Nguyen and M. Saleet Jafri.

13. Rhythmic Ca2+ Oscillations Drive Sinoatrial Nodal Cell Pacemaker Function to Make the Heart Tick: Tatiana M. Vinogradova, Victor A. Maltsev, Konstantin Y. Bogdanov, Alexey E. Lyashkov, and Edward G. Lakatta.

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Part IV: Intracellular Signaling:.

14. Modification of Cellular Communication by Gene Transfer: J. Kevin Donahue, Alexander Bauer, Kan Kikuchi, and Tetsuo Sasano.

15. Caveolae and Lipid Rafts: G Protein-Coupled Receptor Signaling Microdomains in Cardiac Myocytes: Paul A. Insel, Brian P. Head, Rennolds S. Ostrom, Hemal H. Patel, James S. Swaney, Chih-Min Tang, and David M. Roth.

16. Nitric Oxide and the Heart: Update on New Paradigms: C. Belge, Paul B. Massion, M. Pelat, and J. L. Balligand.

17. Cardiac Neurobiology of Nitric Oxide Synthases: Edward J. Danson and David J. Paterson.

18. The Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration: Aldrin V. Gomes, Chenggong Zong, Ricky D. Edmondson, Beniam T. Berhane, Guang-Wu Wang, Steven Le, Glen Young, Jun Zhang, Thomas M. Vondriska, Julian P. Whitelegge, Richard C. Jones, Irving G. Joshua, Sheeno Thyparambil, Dawn Pantaleon, Joe Qiao, Joseph Loo, and Peipei Ping.

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Part V: Energetics and Transport:.

19. Metabolic Energetics and Genetics in the Heart: Heinrich Taegtmeyer, Christopher R. Wilson, Peter Razeghi, and Saumya Sharma.

20. The Sarcomeric Control of Energy Conversion: Carmit Levy, Henk E.D.J. Ter Keurs, Yael Yaniv, and Amir Landesberg.

21. Structure-Function Relation of the Myosin Motor in Striated Muscle: Massimo Reconditi, Marco Linari, Leonardo Lucii, Alex Stewart, Yin-Biao Sun, Theyencheri Narayanan, Tom Irving, Gabriella Piazzesi, Malcolm Irving, and Vincenzo Lombardi.

22. Mitochondria and Ischemia/Reperfusion Injury: Henry M. Honda, Paavo Korge, and James N. Weiss.

23. Regulation of Cardiac Energetics: Role of Redox State and Cellular Compartmentation during Ischemia: Marco E. Cabrera, Lufang Zhou, William C. Stanley, and Gerald M. Saidel.

24. Spatial Regulation of Intracellular pH in the Ventricular Myocyte: Pawel Swietach and Richard D. Vaughan-Jones.

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Part VI: Electromechanical Interactions and Modeling:.

25. Cardiac Systems Biology: Andrew D. McCulloch and Giovanni Paternostro.

26. Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging: Patrick Helm, Mirza Faisal Beg, Michael I. Miller, and Raimond L. Winslow.

27. Electrotonic Cell-Cell Interactions in Cardiac Tissue: Effects on Action Potential Propagation and Repolarization: Yoram Rudy.

28. Modulation of Transmural Repolarization: Charles Antzelevitch.

29. Species- and Preparation-Dependence of Stretch Effects on Sino-Atrial Node Pacemaking: Patricia J. Cooper and Peter Kohl.

30. Dependence of Electrical Coupling on Mechanical Coupling in Cardiac Myocytes: Insights Gained from Cardiomyopathies Caused by Defects in Cell-Cell Connections: Jeffrey E. Saffitz.

31. Spatial Nonuniformity of Contraction Causes Arrhythmogenic Ca2+ Waves in Rat Cardiac Muscle: Henk E.D.J. Ter Keurs, Yuji Wakayama, Masahito Miura, Bruno D. Stuyvers, Penelope A. Boyden, and Amir Landesberg.

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Part VII: Novel Therapeutics for the Failing and Arrhythmogenic Cardiac Cell:.

32. Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy: Xander H.T. Wehrens, Stephan E. Lehnart, and Andrew R. Marks.

33. Stem Cells for Cardiomyocyte Regeneration: State of the Art: Cesare Peschle and Gianluigi Condorelli.

34. Extracellular Stimulation in Tissue Engineering: Dror Seliktar.

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Part VIII: Epilogue: A View into the Future:.

35. Multiscale Modeling of Cardiac Cellular Energetics: James B. Bassingthwaighte, Howard J. Chizeck, Les E. Atlas, and Hong Qian