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Imaging and the Aging Brain

Mony J. de Leon (Editor), Donald A. Snider (Editor), Howard Federoff (Editor)
ISBN: 978-1-57331-659-0
252 pages
April 2007, Wiley-Blackwell
Imaging and the Aging Brain (1573316598) cover image
Advances in imaging are occurring at a brisk pace, and imaging techniques have great potential to act as pre-symptomatic predictors of disease as well as to chart the course of a disease. Neuroimaging has greatly advanced the understanding of brain function and its relationship to the anatomical substrate. This volume brings together internationally renowned imaging scientists, those studying the aging brain, industry experts, and clinicians to jointly examine the most current methods and their application to brain physiology, behavior, and age-related diseases.

These reports explore new technologies, data from recent neuroimaging initiatives, and translational research applications. Topics covered include (1) in vivo imaging of molecules, cells, and networks throughout the lifespan, (2) cutting edge imaging technologies and studies of the physiology of aging, (3) translational application of neuroimaging, and (4) emerging technologies in the private sector.

This volume is the proceedings of a meeting that celebrated the 25th anniversary of the American Federation for Aging Research and its longstanding history of philanthropy in the area of aging research.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

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Foreword: Mony J. De Leon.

Part I: In Vivo Imaging of Molecules, Cells, and Networks in Aging and Animal Models of Alzheimer's:.

1. Making New Memories: The Role of the Hippocampus in New Associative Learning: Wendy A. Suzuki.

2. Anatomical and Functional Phenotyping of Mice Models of Alzheimer’s Disease by MR Microscopy: Helene Benveniste, Yu Ma, Jasbeer Dhawan, Andrew Gifford, S. David Smith, Igor Feinstein, Congwu Du, Samuel C. Grant, and Patrick R. Hof.

3. Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease: Jaime Grutzendler, Kathryn Helmin, Julia Tsai, and Wen-Biao Gan.

4. Two-Photon Imaging of Astrocytic Ca2+ Signaling and the Microvasculature in Experimental Mice Models of Alzheimer’s Disease: Takahiro Takano, Xiaoning Han, Rashid Deane, Berislav Zlokovic, and Maiken Nedergaard.

5. Synaptic and Mitochondrial Morphometry Provides Structural Correlates of Successful Brain Aging: Carlo Bertoni-Freddari, Patrizia Fattoretti, Belinda Giorgetti, Yessica Grossi, Marta Balietti, Tiziana Casoli, Giuseppina Di Stefano, and Gemma Perretta.

6. Impaired Recognition Memory and Decreased Prefrontal Cortex Spine Density in Aged Female Rats: Maureen Wallace, Maya Frankfurt, Adolfo Arellanos, Tomoko Inagaki, and Victoria Luine.

7. Alzheimer Amyloid β-Peptide A-β25−35 Blocks Adenylate Cyclase-Mediated Forms of Hippocampal Long-Term Potentiation: Blaine E. Bisel, Kristen M. Henkins, and Karen D. Parfitt.

8. Age-Related Changes in Neuronal Susceptibility to Damage: Comparison of the Retinal Ganglion Cells of Young and Old Mice Before and After Optic Nerve Crush: Ai Ling Wang, Ming Yuan, and Arthur H. Neufeld.

Part II: In Vivo Imaging of Human Aging and the Transition to Cognitive Impairment:.

9. Top-Down Modulation and Normal Aging: Adam Gazzaley and Mark D'Esposito.

10. Brain Aging and Its Modifiers: Insights from in Vivo Neuromorphometry and Susceptibility Weighted Imaging: Naftali Raz, Karen M. Rodrigue, and E. Mark Haacke.

11. Linking Brain Imaging and Genomics in the Study of Alzheimer's Disease and Aging: Eric M. Reiman.

12. Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer’s Disease: M. J. De Leon, L. Mosconi, K. Blennow, S. Desanti, R. Zinkowski, P. D. Mehta, D. Pratico, W. Tsui, L. A. Saint Louis, L. Sobanska, M. Brys, Y. Li, K. Rich, J. Rinne, and H. Rusinek.

13. Functional MRI Studies of Associative Encoding in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease: Reisa Sperling.

14. Quantitative EEG and Electromagnetic Brain Imaging in Aging and in the Evolution of Dementia: Leslie S. Prichep.

15. [123I]5-IA-85380 SPECT Imaging of β2-Nicotinic Acetylcholine Receptor Availability in the Aging Human Brain: Effie M. Mitsis, Kelly P. Cosgrove, Julie K. Staley, Erin B. Frohlich, Frederic Bois, Gilles D. Tamagnan, Kristina M. Estok, John P. Seibyl, and Christopher H. Van Dyck.

16. Role of Aerobic Fitness and Aging on Cerebral White Matter Integrity: Bonita L. Marks, David J. Madden, Barbara Bucur, James M. Provenzale, Leonard E. White, Roberto Cabeza, and Scott A. Huettel.

17. Age-Related Changes in Nociceptive Processing in the Human Brain: Raimi L. Quiton, Steven R. Roys, Jiachen Zhuo, Michael L. Keaser, Rao P. Gullapalli, and Joel D. Greenspan.

18. Magnetic Resonance Spectroscopy and Environmental Toxicant Exposure: Marc G. Weisskopf.

Part III: Diagnostic Applications of Imaging to Alzheimer's Disease:.

19. Tracking Alzheimer's Disease: Paul M. Thompson, Kiralee M. Hayashi, Rebecca A. Dutton, Ming-Chang Chiang, Alex D. Leow, Elizabeth R. Sowell, Greig De Zubicaray, James T. Becker, Oscar L. Lopez, Howard J. Aizenstein, and Arthur W. Toga.

20. Shifting Paradigms in Dementia: Toward Stratification of Diagnosis and Treatment Using MRI: Wiesje M. Van Der Flier, Frederik Barkhof, and Philip Scheltens.

21. Imaging-Guided Microarray: Isolating Molecular Profiles That Dissociate Alzheimer's Disease from Normal Aging: Ana Carolina Pereira, William Wu, and Scott A. Small.

22. Fibrillar and Oligomeric β-Amyloid as Distinct Local Biomarkers for Alzheimer's Disease: Michael C. Montalto, Gill Farrar, and Cristina Tan Hehir.

23. Diffusion Tensor Imaging of Normal Appearing White Matter and Its Correlation with Cognitive Functioning in Mild Cognitive Impairment and Alzheimer's Disease: Juebin Huang and Alexander P. Auchus.

24. Enhanced Ryanodine-Mediated Calcium Release in Mutant PS1-Expressing Alzheimer's Mouse Models: Grace E. Stutzmann, Ian Smith, Antonella Caccamo, Salvatore Oddo, Ian Parker, and Frank Laferla.

25. Prospects for Prediction: Ethics Analysis of Neuroimaging in Alzheimer's Disease: J. Illes, A. Rosen, M. Greicius, and E. Racine.

Index of Contributors.

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