Plenary Lecture: Luisa Massimo, Genoa, Italy.

Part I: Estrogens, Development and Cancer:.

1. Estrogens In Prostate Development: Gail S. Prins.

2. Timing of Dietary Estrogenic Exposures and Breast Cancer Risk: Leena A. Hilakivi-Clarke.

3. From Adult Stem Cells to Cancer Stem Cells: OCT-4 Gene, Cell-Cell Communication and Hormones During Tumor Promotion: James E. Trosko.

4. Hormonal Regulation of Human Mammary Stem and Progenitor Cells: Max S. Wicha.

5. Environmental Estrogen Signaling: John A. McLachlan.

Part II: New Insights into Estrogen Action:.

6. Recent Advances in Estrogen Signaling: Jan-Åke Gustaffson.

7. Lessons in Estrogen Biology from Knockout and Transgenic Animals: Kenneth S. Korach.

8. Integration of the Extra-Nuclear and Nuclear Actions of Estrogen: Ellis R. Levin.

9. Chromatin Remodelling by Estrogen and Progestin: Miguel Beato.

10. Estrogens and Epigenetic Signals: Richard G. Pestell.

Part III: Estrogens and Cancer I: Breast Cancer:.

11. The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence: Paola Muti.

12. Sustainable Lifestyle Changes for Breast Cancer Prevention: Franco Berrino.

13. The Role of Gene Silencing in Cancer Development and Progression: New Therapeutic and Prevention Targets: Frank J. Rauscher 3rd.

14. Recent Results from Clinical Trials Using SERMS to Reduce the Risk of Breast Cancer: Victor Vogel.

15. Antihormones in Prevention and Treatment of Breast Cancer: Piero Sismondi.

Part IV: Estrogen and Cancer II: Prostate Cancer:.

16. Sex Steroids and Prostate Carcinogenesis: An Integrated, Multifactorial Working Hypothesis: Maarten C. Bosland.

17. Estrogens and Antiestrogens in Prostate Carcinogenesis: Key Mediators and Therapeutic Candidates: Shuk-Mei Ho.

18. Extranuclear Cross-Talk Between Androgen and Estradiol Receptors in Prostate and Breast Cancer Cells: Ferdinando Auricchio.

19. Estrogens and Mechanisms of Prostate Cancer Progression: Giuseppe Carruba.

20. Potential Therapeutic Targets of Estrogen and Selective Estrogen Receptor Modulators: Pirkko Härkönen.

Part V: Estrogens and Cancer III: Liver Cancer:.

21. [Title To Be Defined]: Giuseppe Montalto.

22. [Title To Be Defined]: Colin P. Smith.

23. Aromatase and Estrogen Formation in Human Liver Tissues and Cells: Shiuan Chen.

24. Antiestrogen and Serms in Human Hepatocellular Carcinoma.

25. Catechol Quinones of Estrogens and Dopamine in the Initiation of Cancer and Neurodegenerative Diseases: Ercole Cavalieri.

Part VI: Estrogens and Neurodegenerative Disorders:.

26. Estrogens in the Nervous System: Mechanisms and Nonreproductive Functions: Adriana Maggi.

27. Neuroprotective Action of Estrogens: Roberta Brinton.

28. Estrogen and Alzheimer’s Disease: Samuel E. Gandy.

29. A Potential Role for Estrogen in Multiple Sclerosis: Halina Offner.

Part VII: The Puzzle of Myelodysplastic Syndrome: Focusing on Immunophenotyping, Cytogenetics and Molecular Genetics:.

30. The Role of Flow Cytometric Immunophenotyping in Myelodysplastic Syndrome: Guido Pagnucco.

31. Clinical Relevance of Cytogenetics in Myelodysplastic Syndrome: Paolo Bernasconi.

32. Genetic Abnormalities as Targets for Molecular Therapies in Myelodysplastic Syndrome: Daniela Cilloni.

Part VIII: Estrogens and Cardiovascular Diseases:.

33. Novel Mechanisms of Estrogen Signaling in Endothelial Cells: Tommaso Simoncini.

34. Estrogen Action and Metabolism in Smooth Muscle Cells of Human Vessels: Mariam Klouche.

35. The Effects of HRT on Cardiovascular System: Mechanisms and Implications: John C. Stevenson.

36. Implications of Recent Clinical Trials of Postmenopausal Hormone Therapy for Management of Cardiovascular Disease: Jacques E. Rossouw.

Part IX: Estrogens and Immune Diseases:.

37. [Title To Be Defined]: Claudio Franceschi.

38. Genetics, Gender and Longevity: Calogero Caruso.

39. Age-Related Inflammatory Diseases: Role of Genetics and Gender: Giuseppina Candore.

40. Estrogen as an Immunomodulator: Thomas J. Lang.

41. Steroid Hormones Regulate Replenishment of the Immune System: Paul W. Kincade.

42. Estrogens in Autoimmune Diseases: Maurizio Cutolo