This volume highlights new insights into the mechanisms of bone development, including cellular and mechanical factors, receptors, and signaling pathways and their role in both normative and pathologic states of bone.

The first of two volumes, the volume comprises three sections: (1) insights into skeletal development, including, among others, novel ideas about the role of the perichondrium in skeletogenesis, current studies on joint formation, and the human consequences of dysregulated morphogenic signaling; (2) a traditional series of papers, both reviews and original research articles on bone cells—osteoblasts, osteoclasts, and osteocytes—in relation to mechanisms underlying their formation, fate, and function; and (3) new information on the role of hormones, both steroids and peptides, as well as cytokines and the central nervous system in regulating skeletal remodeling.

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