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Barriers and Channels Formed by Tight Junction Proteins I

ISBN: 978-1-57331-873-0
252 pages
June 2012, Wiley-Blackwell
Barriers and Channels Formed by Tight Junction Proteins I (1573318736) cover image

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).  Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system

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1. Perspectives on tight junction research
Jörg-Dieter Schulzke, Dorothee Günzel, Lena J. John, and Michael Fromm

Molecular properties of the tight junction

20. Charge-selective claudin channel
Susanne M. Krug, Dorothee Günzel, Marcel P. Conrad, In-Fah M. Lee, Salah Amasheh, Michael Fromm, and Alan S. L. Yu

29. Claudin-derived peptides are internalized via specific endocytosis pathways
Denise Zwanziger, Christian Staat, Anuska V. Andjelkovic, and Ingolf E. Blasig

38. A phosphorylation hotspot within the occluding C-terminal domain
Max J. Dörfel and Otmar Huber

45. Determinants contributing to claudin ion channel formation
Anna Veshnyakova, Susanne M. Krug, Sebastian L. Mueller, Jörg Piontek, Jonas Protze, Michael Fromm, and Gerd Krause

54. Lipolysis-stimulted lipoprotein receptor: a novel membrane protein of tricellular tight junctions
Mikio Furuse, Yukako Oda, Tomohito-Higashi, Noriko Iwamoto, and Sayuri Masuda

59. Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies
Jan Rossa, Dorothea Lorenz, Martina Ringling, Anna Veshnyakova, and Joerg Piontek

67. Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis
Christine Rueckert, Victor Castro, Corinna Gagell, Sebastian Dabrowski, Michael Schümann, Eberhard Krause, Ingolf E. Blasig, and Reiner F. Haseloff

77. Dynamic properties of the tight junction barrier
Christopher R. Weber

Regulation of the tight junction and barrier function

85. Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells
Takashi Kojima and Norimasa Sawada

93. The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation
Michael Scharl and Gerhard Rogler

103. Caveolin binds independently to claudin-2 and occluding
Christina M. Van Itallie and James M. Anderson

108. Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2
Declan F. McCole

115. Intracellular mediators of JAM-A-dependent epithelial barrier function
Ana C. Monteiro and Charles A. Parkos

125. Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex
Sandra Citi, Pamela Pulimeno, and Serge Paschoud

133. ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis
Lorenza Gonzalez-Mariscal, Pablo Bautista, Susana Lechuga, and Miguel Quiros

142. From TER to trans- and paracellular resistance: lessons from impedance spectroscopy
Dorothee Günzel, Silke S. Zakrzewski, Thomas Schmid, Maria Pangalos, John Wiedenhoeft, Corinna Blasse, Christopher Ozboda, and Susanne M. Krug

Tight junctions in skin, lung, endothelia, and nervous tissues

152. Diverse type of junctions containing tight junction proteins in stratified mammalian epithelia
Werner W. Franke and Ulrich-Frank Pape

158. Barriers and more: functions of tight junction proteins in the skin
Nina Kirschner and Johanna M. Brandner

167. Roles for claudins in alveolar epithelial barrier function
Christian E. Overgaard, Leslie A. Mitchell, and Michael Koval

175. Claudins and alveolar epithelial barrier function in the lung
 James A. Frank

184. Relevance of endothelial junctions in leukocyte extravasation and vascular permeability
Dietmar Vestweber

193. Involvement of claudins in zebrafish brain ventricle morphogenesis
Jingjing Zhang, Martin Liss, Hartwig Wolburg, Ingolf E. Blasig, and Salim Abdelilah-Seyfried

199. Modulation of tight junction proteins in the perineurium for regional pain control
D. Hackel, A. Brack, M. Fromm, and K. L. Rittner

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