Resveratrol and Health: 2nd International Conference on Resveratrol and Health, Volume 1290
August 2013, Wiley-Blackwell
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phenol
phytoalexin derived from grapes, berries, and other plants
possessing a spectrum of pharmacologic properties.
Resveratrol has been shown to modulate LDL levels, a major risk
factor for cardiovascular disease, to interfere with or inhibit
oncogenesis and tumor proliferation in in vivo animal cancer
models and in human tumor cells in vitro, to significantly
extend the lifespan of the yeastSaccharomyces
elegans and the fruit fly Drosophila
melanogaster, and to produce wide-ranging benefits in
animal models of obsesity and diabetes.Resveratrol has gained
mainstream attention as “the red wine pill,” with
widespread claims made of human health benefits that have outpaced
the existing evidence. Over the past few years, many clinical
trials have been conducted to evaluate the health effects of
resveratrol in humans, in the treatment of cancer, cardiovascular
disease, obesity, diabetes, osteopenia and osteoporosis, and
others. Considerable work is also underway exploring the
optimization of resveratrol delivery and bioavailability in
nutraceutical and pharmaceutical paradigms.
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