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The Epilepsy Aphasia Spectrum: From Landau-Kleffner Syndrome to Rolandic Epilepsy

ISBN: 978-1-909962-76-7
200 pages
January 2017
The Epilepsy Aphasia Spectrum: From Landau-Kleffner Syndrome to Rolandic Epilepsy (1909962767) cover image

Description

Landau-Kleffner syndrome (LKS) is a rare childhood neurological syndrome. It is characterised by a sudden or gradual loss of ability to understand of express language (aphasia) and usually occurs in children between the ages of 3 and 7 years. Rolandic epilepsy is the most common epilepsy syndrome in childhood with involvement of the oropharyngeal manifestations, hypersalivation and arrest of speech. These two syndromes are considered to be aspects of the ‘epilepsy-aphasia spectrum’ with common rolandic epilepsy being the mildest form and LKS the most severe.
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Table of Contents

Authors’ Appointments vii

Forewords ix

Preface xi

Acknowledgements xiii

1. Introduction 1

2. History of the Landau–kleffner Syndrome 4

3. Classification Issues 18

4. Speech Perception and Brain Organization of Language: Relevant Features for Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum 26

5. The Different Clinical Facets of Landau–kleffner Syndrome 34

6. Developmental Aspects of Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum and The Overlap with Developmental Language Disorders and Autism Spectrum Disorder 60

7. Evolution of Landau–kleffner Syndrome: Short-,mid- and long-term Outcomes 70

8. From Rolandic Epilepsy to Landau–kleffner Syndrome 78

9. Laboratory Investigations in Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum 95

10. Physiopathology of Speech, Language and Other Prolonged Epileptic Dysfunction in Landau–kleffner Syndrome, Epilepsy with Continuous Spike Waves During Sleep and Related Syndromes 106

11. Functional Neuroimaging Investigations in Idiopathic Focal Epilepsies of Childhood with Cognitive and Behavioural Impairment 119
Xavier de Tiège, Serge Goldman, and Patrick van Bogaert

12. Drug Management of Cognitive Impairments in Landau–kleffner Syndrome and Other Epilepsy Aphasia Spectrum Syndromes 127

13. Speech and Language, Educational and Psychological Remediation 137

14. Personal Testimonies and Unpublished Cases 156

15. Summary and Conclusions 167

References 170

Index 187

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