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Bioorganic Chemistry: Highlights and New Aspects

ISBN: 978-3-527-29665-1
456 pages
December 1999
Bioorganic Chemistry: Highlights and New Aspects (3527296654) cover image
The understanding of (patho)physiological processes - the biosynthesis of biomolecules such as enzymes, nucleic acids, and secondary metabolites; the pathways of signaltransduction; or the function of pharmaceutical agents - is of increasing importance not only for drug research but also for the development of new synthetic methods in organic chemistry and biochemistry. In a truly interdisciplinary way bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, organic chemistry, and spectroscopy.
This book fills a void in this rapidly growing field of chemistry and gives a thorough yet understandable introduction for advanced students and researchers alike. Contributions of more than sixty scientists provide a topical overview of recent advances in: drug development based on natural products; the biosynthesis, activity, and application of enzymes; carbohydrates; peptides; nucleic acids; analytical methods in bioorganic chemistry.
This book will be an appetizer for all - students and researchers alike - seeking orientation in this fascinating field of chemistry.
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DRUGS AND SEARCH FOR LEAD STRUCTURES
Marine Alkaloids
Leukotriene Derivates
Diazoketones for the Synthesis of Beta-Lactams
Selenium Compounds in Biochemical Oxidations
Galaktophingolipid, etc
ENZYMOLOGY
Enzyme Catalyzed Diels-Alder Reactions
Enzymatic Halogenation in Bacteria
Biotransformations in the Stereoselective Synthesis of Cyclophanes, etc
CARBOHYDRATES
Mannosid Clusters
Glycoconjugates in Cancer Therapy, etc
PEPTIDES
Cyclodepsipeptides
Synthetic Adrenaline and Peptide Receptors
Substituted and Beta-Amino Acids as Building Blocks for Peptide Mimetics
Carbohydrate-Protein Interactions, etc.
NUCLEIC ACIDS
Reparing Dna
In Vitro Selection
Studies on Hairpin Ribozymes
New Pna Buiding Block for Antisense Research, etc.
BIOCHEMISTRY
Activity of Neuropeptide Y
Oligosaccharide Antibiotics
Biosynthesis of Plant Xanthones
Manipulating Intracellular Signal Transductions
Methyl-Transfer Reactions, etc.
SYNTHETIC AND ANALYTICAL METHODS
Constitutional Assignment of Marine Natural Products
Radical Induced Reactions in Biological Systems
Multivariate Analysis of Biotransformations, etc.
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