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Phosgenations: A Handbook

ISBN: 978-3-527-29823-5
668 pages
February 2004
Phosgenations: A Handbook (3527298231) cover image


In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalylchloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The result is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound - including the safety phosgenation.
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Table of Contents


1. Contradictions.

2. Phosgenation Reagents.

3. Evaluation of Phosgenation Reagents.

4. Phosgenation Reactions.

5. Topics on Specific Synthetic Applications of  Phosgenation Reactions.

6. Evaluation of Phosgenation Reactions.

7. Materials and Resources for Phosgenation Reagents.

8. Monitoring Phosgene and Phosgene Substitutes: Analytical Methods.

9. Outlook.



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Author Information

Livius Cotarca was born in Romania (1951) where he received his M .Sc. and PhD degrees in Industrial Organic Chemistry from the Polytechnic University of Timisoara. He holds also a M. Sc. Degree in Chemical Engineering from the Milan Polytechnic University (Italy). He was successively Associate Professor of Organic Chemistry at Timisoara and Senior Chemist at Caffaro-Sinia, Italy. In 1999 he joined the Zamban Group where he is now Manager of Research and Industrial Development. Dr. Cotarca is a recipient of the Nicolae Teclu Award for Chemistry of Romanian Academy and is a member of the American Chemical Society. He is author of numerous patents and publications and co-author of two books. Currently, his scientific interest is devoted to the process chemistry of active pharmaceutical ingredients.

Heiner Eckert was born in Munich, Germany, where he gained his diploma in Chemistry at the Technical University of Munich (TUM) in 1973, going on to receive his PhD with “summa cum laude” under Professor I. Ugi three years later. In 1977, he founded “Dr. Eckert GmbH”, a company specializing in developing fine chemicals and processes for chemicals production, particularly in the field of phosgenation reactions. At present he is working as an Academic Director at the TUM, with his research focused on new methods in organic syntheses development. Dr. Eckert has published numerous scientific publications and patents, and indeed the “Eckert hydrogenation catalysts” are named for him.

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"…unique, one of the year's best information resources." (E-STREAMS, December 2004)

"…provides a good survey on the chemistry of phosgene and its derivatives." (Synthesis, September 2006)

"The encyclopaedic nature of this book, combined with its critical, informed, and comprehensive approach, makes it a very valuable source for synthetic chemists in academia and in industry."
—Peter L. Spargo, Organic Research Process and Development

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