INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays