Foreword.

Contributors.

PART I: MOLECULAR TARGETS.

1. Cellular Assays in Drug Discovery (H. Albrecht, et al.).

2. Gene Knockout Models (P. Ruth & M. Sausbier).

3. Reporter Gene Assay Systems for the Investigation of G-protein-coupled Receptors (M. Dinger & A. Beck-Sickinger).

4. From the Human Genome to New Drugs: The Potential of Orphan G-protein-coupled Receptors (R. Bakker & R. Leurs).

PART II: SYNTHESIS.

5. Stereoselective Synthesis with the Help of Recombinant Enzymes  (N. Rao & A. Liese).

6. Nucleic Acid Drugs (J. Engels & J. Parsch).

PART III: ANALYSIS.

7. Recent Trends in Enantioseparation of Chiral Drugs (B. Chankvetadze).

8. Affinity Chromatography (G. Scriba).

9. Nuclear Magnetic Resonance-based Drug Discovery (U. Günther, et al.).

10.¹³C- and ¹⁵N-Isotopic Labeling of Proteins (C. Klammt, et al.).

11. Application of Antibody Fragments as Crystallization Enhancers (C. Hunte & C. Münke).

PART IV: KINETICS, METABOLISM AND TOXICOLOGY.

12. Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response (K. Kesseler).

13. Pharmacogenomics of Bioavaliability and Elimination (I Cascorbi & H. Kroemer).

14. Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology (W. Heijne, et al.).

Index.