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Protein-Ligand Interactions: From Molecular Recognition to Drug Design
Hans-Joachim Böhm (Editor), Gisbert Schneider (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)
ISBN: 978-3-527-30521-6
Hardcover
262 pages
May 2003
US $175.00 Add to Cart

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  • Description
  • Table of Contents
  • Reviews
Preface.

A Personal Foreword.

List of Contributors.

List of Abbreviations.

Prologue (D. Brown).

Prediction of Non-bonded Interactions in Drug Design (H. Böhm).

Introduction to Molecular Recognition Models (H. Schneider).

Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions (R. Raffa).

The Biophore Concept (S. Pickett).

Receptor-Ligand Interaction (M. Höfliger & A. Beck-Sickinger).

Hydrogen Bonds in Protein-Ligand Complexes (M. Williams & J. Ladbury).

Principles of Enzyme-Inhibitor Design (D. Banner).

Tailoring Protein Scaffolds for Ligand Recognition (A. Skerra).

Small Molecule Screening on Chemical Microarrays (G. Metz, et al.).

Subject Index.

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