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Carbohydrate-based Drug Discovery, Two Volumes
Chi-Huey Wong (Editor)
ISBN: 978-3-527-30632-9
Hardcover
980 pages
November 2003
US $525.00 Add to Cart

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  • Description
  • Table of Contents
  • Author Information
  • Reviews
VOLUME 1.

Preface.

List of Contributors.

1. Synthetic Methodologies (C. Saotome and O. Kanie).

2. Complex Carbohydrate Syntyhesis (M. Kiso, et al.).

3. The Chemistry of Sialic Acid (G. Boons and A. Demchenko).

4. Solid-Phase Oligosaccharide Synthesis (P. Seeberger).

5. Solution and Ploymer-Supported Synthesis of Carbohydrates (S. Nishimura).

6. Enzymatic Synthesis of Oligosaccharides (J. Zhang, et al.).

7. Glycopeptides and Glycoproteins: Synthesis Chemistry and Biology (O. Seitz).

8. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1 (K. Nicolaou, et al.).

9. Chemical Synthesis of Asparagine-Linked Glycoprotein Oligosaccharides: Recent Examples (Y. Ito and I. Matsuo).

10. Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation (B. Imperiali and V. Tai).

11. Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides (P. Goekjian, et al.).

12. Synthesis Lipid A Antagonists for Sepsis Treatment (W. Christ, et al.).

13. Polysialic Acid Vaccines (H. Jennings).

14. Synthesis Carbohydrate-Based Vaccines (S. Keding and S. Danishefsky).

15. Chemistry, Biochemistry, and Pharmaceutial Potentials of Glycosaminoglycans and Related Saccharides (T. Islam and R. Linhardt).

16. A New Generation of Antithrombotics Based on Synthetic Oligosaccharides (M. Petitou and J. Herbert).

VOLUME 2.

17. Sequencing of Oligosaccharides and Glycoproteins (S. Haslam, et al.).

18. Preparation of Heterocyclic 2-Deoxystreptamine Aminoglycoside Analogues and Characterization of their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry (R. Griffey, et al.).

19. Glycosylation Aanalysis of a Recombinant P-Selectin Antagonist by High-pH Anion-Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (M. Hardy and R. Cornell).

20. Analytical Techniques for jthe Characterization and Sequencing of Glycosaminoglycans (R. Sasisekharan, et al.).

21. Thermodynamic Models of the Multivalency Effect (P. Kitov and D. Bundle).

22. Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes (L. Kiessling, et al.).

23. Glycosyltransferase Inhibitors (K. Jung and R. Schmidt).

24. RNA-Aminoglycoside Interactions (H. Weizman and Y. Tor).

25. Glycosylated Natural Products (J. Thorson and T. Vogt).

26. Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars (A. Wong, et al.).

27. Neoglycolipids: Identification of Functional Carbohydrate Epitopes (T. Feizi, et al.).

28. A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics (M. Mylvaganam and C. Lingwood).

29. Small Molecule Inhibitors of the Sulfotransferases (D. Verdugo, et al.).

30. Carbohydrate-Based Treatment of Cancer Metastasis (R. Kannagi).

31. N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents (R. Thomson and M. von Itzstein).

32. Modified and Modifying Sugars as a New Tools for the Development of Therapeutic Agents - The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine (R. Horstkorte, et al.).

33. Modified and Modifying Sugars as a New Tools for the Development of Therapeutic Agents - Glycosidated Phospholipids as a New Type of Antiproliferative Agents (K. Danker, et al.).

34. Glycoside Primers and Inhibitors of Glycosylation (J. Brown, et al.).

35. Carbohydrate-Based Drug Discovery in the Battle Against Bacterial Infections: New Opportunities Arising from Programmable One-Pot Oligosaccharide Synthesis (T. Ritter and C. Wong).

Subject Index.

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