 Protein Crystallography in Drug Discovery
ISBN: 978-3-527-30678-7
Hardcover
278 pages
March 2004
US $175.00
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A Personal Foreword.
List of Contributors.
1. Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes (Robert E. Babine).
2. Kinases (Jerry L. Adams, James Veal, and Lisa Shewchuk).
3. The Proteasome as a Drug Target (Tsunehiro Mizushima and Tomitake Tsukihara).
4. Antibiotics and the Ribosome (Jeffrey L. Hansen).
5. Structure-Based Design of Cathepsin K Inhibitors (Daniel F. Veber and Maxwell D. Cummings).
6. Structure-Based Design of Potent and Selective Cdk4 Inhibitors (Teruki Honma).
7. Crystallization and Analysis of Serine Proteases with Ecotin (Sandra M. Waugh and Robert J. Fletterick).
8. X-ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs (Donald F. Doyle and Lauren J. Schwimmer).
9. Engineering Proteins to Promote Crystallization (Lei Jin and Robert E. Babine).
10. High-throughput Crystallography (Harren Jhoti).
11. Micro-Crystallization (Carl L. Hansen, Morten Sommer, Kyle Self, James M. Berger, and Stephen R. Quake).
Subject Index.
