A Personal Foreword.

List of Contributors.

Introduction (G. Müller & H. Kubinyi).

I: GENERAL ASPECTS.

1. Target Family-directed Masterkeys in Chemogenomics (G. Müller).

2. Drug Discovery from Side Effects (H. Kubinyi).

3. The Value of Chemical Genetics in Drug Discovery (K. Russell & W. Michne).

4. Structural Aspects of Binding Site Similarity: A 3D Upgrade for Chemogenomics (A. Bergner & J. Günther).

II: TARGET FAMILIES.

5. The Contribution of Molecular Informatics to Chemogenomics: Knowledge-based Discovery of Biological Targets and Chemical Lead Compounds (E. Jacoby, et al.).

6. Chemical Kinomics (B. Klebl, et al.).

7. Structural Aspects of Kinases and Their Inhibitors (R. Buijsman).

8. A Chemical Genomics Approach for Ion Channel Modulators (K. Baringhaus & G. Hessler).

9. Phosphodiesterase Inhibitors: A Chemogenomic View (M. Hendrix & C. Kallus).

10. Proteochemometrics: A Tool for Modeling the Molecular Interaction Space (J. Wikberg, et al.).

III: CHEMICAL LIBRARIES.

11. Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs (T. Webb).

12. Computational Filters in Lead Generation: Targeting Drug-like Chemotypes (W. Guba & O. Roche).

13. Navigation in Chemical Space: Ligand-based Design of Focused Compound Libraries (G. Schneider & P. Schneider).

14. Natural Product-derived Combinatorial Libraries and Protein Structure Similarity as Guiding Principles for the Discovery of Drug Candidates (M. Koch & H. Waldmann).

15. Combinatorial Chemistry in the Age of Chemical Genomics (R. Joseph & P. Arya).

Index.