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Bioorganometallics: Biomolecules, Labeling, Medicine

Gerard Jaouen (Editor)
ISBN: 978-3-527-30990-0
462 pages
December 2005
Bioorganometallics: Biomolecules, Labeling, Medicine (352730990X) cover image


This first comprehensive book to cover the expanding field of bioorganometallics represents the perfect starting point for beginners but also an excellent source of high quality information for experts in the field.
Edited by a pioneer in the field with an excellent standing within the community, this book begins with the history of bioorganometallics, before going on to cover pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals.
A must for bioinorganic chemists, the pharmaceutical industry, chemists working in organometallics and biochemists.
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Table of Contents

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles
Ruthenium Arene Anticancer Complexes
Organometallics Targeted to Specific Biological Sites: the Development of New Therapies
Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications
Labeling of Proteins with Organometallic Complexes: Strategies and Applications
Organometallic Bioprobes
Organometallic Complexes as Tracers in Non-isotopic Immunoassay
Genosensors Based on Metal Complexes
Supramolecular Host Recognition Processes with Biological Compounds, Organometallic Pharmaceuticals, and Alkali-metal Ions as Guests
Structure and Mechanism of Metalloenzyme Active Sites
Synthetic Models for Bioorganometallic Reaction Centers
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Author Information

Gérard Jaouen he set up the CNRS URA (Associated Research Unit) N° 403, and the UMR
7576 in 1997, of which he is the director. He is now appointed as an exceptional class professor and has been elected as a member of the CNRS national Committee in 1991 and 1995.
Professor Jaouen is the author of 300 papers and 14 reviews, and holds 10 patents. His
achievements in bioorganometallic chemistry has been recognized by the French Academy of
Sciences in 1996, (J. Reynaud award) Moreover he has been elected to the prestigious and elitist "Institut Universitaire de France" in 1997.
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"...an excellent source of information on a rapidly developing field. It is therefore highly recommended to all researchers active in or interested in this area."
Angewandte Chemie International Edition

"This book contains a series of well written articles...
In essence the book is aimed at biochemists and chemists. The former will find many of the articles in the core of the text, detailing the use of organometallics as bioprobes, to be highly informative, providing a useful historical background and a description of the current synergy between organometallic chemistry and bioscience."
Chemistry World

"A strength of this text lies in the diversity of topics that are covered in such a succinct fashion. It will appeal to a broad spectrum of coordination chemists (organometallic to bioinorganic) as well as biochemists and molecular and cellular biologists needing a primer in this area...It should find a place on all library shelves and will no doubt be a routine reference text for specialists in this field."
Journal of Medicinal Chemistry

"This book contains a series of well written articles."
Chemistry World

"... an interesting and valuable resource for those who wish to learn more about the progress and challenges that face the emerging field of bioorganometallic chemistry."
Journal of the American Chemical Society

"... It is worth emphasising that this is the first book devoted to the subject of bioorganometallic chemistry. Is is also noteworthy that this book ist not just a bioorganometrallic version of a bioorganic textbook; in fact, the emphasis of this book is quite different. It is directed much more towards the medicinal allpications of bioorganometallics compounds (although not exclusivley), from the cisplatin-like compounds that are remarkably effective without containing an obvious biological ligand to determince activity, through those which are closer to organic drugs, with an organometallic apendage providing unique and benefical properties, to those where the metal imparts a unique property as in radiopharmaceuticals. ..."

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Bioorganometallics: Biomolecules, Labeling, Medicine (US $277.00)

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