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Bioorganometallics: Biomolecules, Labeling, Medicine

Gerard Jaouen (Editor)
ISBN: 978-3-527-30990-0
462 pages
December 2005
Bioorganometallics: Biomolecules, Labeling, Medicine (352730990X) cover image
This first comprehensive book to cover the expanding field of bioorganometallics represents the perfect starting point for beginners but also an excellent source of high quality information for experts in the field.
Edited by a pioneer in the field with an excellent standing within the community, this book begins with the history of bioorganometallics, before going on to cover pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals.
A must for bioinorganic chemists, the pharmaceutical industry, chemists working in organometallics and biochemists.
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Preface.

List of Contributors.

1 A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles (Gérard Jaouen, Wolfgang Beck, and Michael J. McGlinchey).

1.1 Introduction.

1.2 Organometallics and Therapy.

1.3 Toxicology and the Environment.

1.4 Bioanalytical Methods Based on Special Properties of Organometallic Complexes.

1.5 Naturally-occurring Organometallics and Synthetic Models.

1.6 Organometallic Chemistry and Aqueous Solvents.

1.7 Conclusions.

2 Ruthenium Arene Anticancer Complexes (Michael Melchart and Peter J. Sadler).

2.1 Introduction.

2.2 Metal-based Anticancer Complexes.

2.3 Chemistry of Ru Arenes.

2.4 Biological Activity.

2.5 Mechanism of Action.

2.6 Conclusions.

3 Organometallics Targeted to Specific Biological Sites: the Development of New Therapies (Gérard Jaouen, Siden Top, and Anne Vessières).

3.1 Introduction.

3.2 Overview of Previous Developments.

3.3 Metal Complex SERMs (Selective Estrogen Receptor Modulators).

3.4 The Alkyne Cobalt Carbonyl Complexes.

3.5 Ferroquine, a New Weapon in the Fight Against Malaria: the Archetypical Bioorganometallic Approach.

3.6 Other Examples of Organometallics Complexes Tested for their Biological Activities.

3.7 Conclusion.

4 Radiopharmaceuticals (Roger Alberto).

4.1 What are Radiopharmaceuticals?

4.2 Organometallic Aquo-ions.

4.3 The Prototype [99Tc(OH2)3(CO)3]+, Synthesis and Properties.

4.4 Combining [99Tc(OH2)3(CO)3]+ with Targeting Vectors.

4.5 Perspectives.

5 Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications (Nils Metzler-Nolte).

5.1 Introduction.

5.2 Conjugates of Organometallics with Small Peptides.

5.3 Conjugates of Organometallics with Natural Peptides.

5.4 Conjugates of Organometallics with PNA.

5.5 Applications.

6 Labeling of Proteins with Organometallic Complexes: Strategies and Applications (Michèle Salmain).

6.1 Introduction.

6.2 Redox Probes.

6.3 Luminescent Probes.

6.4 Heavy Metal Probes.

6.5 Metallo–carbonyl Probes for Infrared Spectroscopy.

6.6 Conclusions and Outlook.

7 Organometallic Bioprobes (G. Richard Stephenson).

7.1 Introduction.

7.2 The Definition of the Terms Bioprobes and Molecular Bioprobes.

7.3 Response Strategies for the Read-out of Information.

7.4 Organometallic Components for Organometallic Bioprobes – Opening up the Advantages of IR-based Read-out Methods.

7.5 Selectivity of Responses in IR-based Read-out Methods.

7.6 Examples of Organometalcarbonyl Bioprobe Structures.

7.7 Use of Organometallic Bioprobes with Proteins.

7.8 Power of Genetics in the Design of Bioprobe Experiments.

7.9 Conclusions.

8 Organometallic Complexes as Tracers in Non-isotopic Immunoassay (Michèle Salmain and Anne Vessières).

8.1 Introduction.

8.2 Principle of an Immunoassay.

8.3 Obtaining Specific Antibodies.

8.4 Synthesis of the Organometallic Tracers.

8.5 Examples of Mono- and Multi-metalloimmunoassays (MIA).

8.6 Use of Organometallic Complexes as Substrates or Co-substrates for Enzyme Immunoassay.

8.7 Conclusion.

9 Genosensors Based on Metal Complexes (Shigeori Takenaka).

9.1 Introduction.

9.2 Metal Complexes as DNA Probes.

9.3 Electrochemical Analysis of the Interaction of Metal Complexes with dsDNA.

9.4 Gene Detection Based on a Cationic Metal Complex or Metal Complex Conjugated with DNA-binding Ligand.

9.5 Gene Detection Based on Ferrocenyl Oligonucleotides as a Metal Complex Conjugated with DNA Fragments.

9.6 Conclusion.

10 Supramolecular Host Recognition Processes with Biological Compounds, Organometallic Pharmaceuticals, and Alkali-metal Ions as Guests (Richard H. Fish).

10.1 Introduction.

10.2 Host 1.

10.3 A New Host, trans-[Cp*Rhη1-(N3)-1-methylcytosine)(μ-OH)]2(OTf)2 2.

10.4 Computer Docking Experiments of Organometallic Pharmaceuticals at Estrogen Receptor Binding Sites: Selective, Non-Covalent Interactions with Hormone Proteins.

10.5 Organometallic Ionophores.

10.6 Overall Conclusions for Molecular Recognition.

11 Structure and Mechanism of Metalloenzyme Active Sites (Juan C. Fontecilla-Camps).

11.1 Introduction.

11.2 Copper.

11.3 Iron.

11.4 Manganese.

11.5 Molybdenum and Tungsten.

11.6 Nickel.

11.7 Zinc.

11.8 Conclusions.

12 Synthetic Models for Bioorganometallic Reaction Centers (Rachel C. Linck and Thomas B. Rauchfuss).

12.1 Introduction.

12.2 Fe-only Hydrogenase.

12.3 NiFe Hydrogenases.

12.4 Acetyl CoA Synthase.

12.5 Anaerobic Carbon Monoxide Dehydrogenase.

12.6 Aerobic Carbon Monoxide Dehydrogenase.

12.7 Methyl Coenzyme M Reductase.

12.8 Conclusions.

Subject Index.

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Gérard Jaouen he set up the CNRS URA (Associated Research Unit) N° 403, and the UMR 7576 in 1997, of which he is the director. He is now appointed as an exceptional class professor and has been elected as a member of the CNRS national Committee in 1991 and 1995.
Professor Jaouen is the author of 300 papers and 14 reviews, and holds 10 patents. His achievements in bioorganometallic chemistry has been recognized by the French Academy of Sciences in 1996, (J. Reynaud award) Moreover he has been elected to the prestigious and elitist "Institut Universitaire de France" in 1997.
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"It should find a place on all library shelves and will no doubt be a routine reference text for specialists in this field." (Journal of Medicinial Chemistry, August 10, 2006)

"…an interesting and valuable resource for those who wish to learn more about the progress and challenges that face the emerging field of bioorganometallic chemistry." (Journal of the American Chemical Society, August 2, 2006)

"...an excellent source of information on a rapidly developing field. It is therefore highly recommended to all researchers active in or interested in this area." (Angewandte Chemie International Edition)

"In essence the book is aimed at biochemists and chemists. The former will find many of the articles in the core of the text, detailing the use of organometallics as bioprobes, to be highly informative, providing a useful historical background and a description of the current synergy between organometallic chemistry and bioscience." (Chemistry World)

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