 Industrial Biotransformations, 2nd, Completely Revised and Enlarged Edition
ISBN: 978-3-527-31001-2
Hardcover
570 pages
May 2006
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Preface to the second edition.
List of Contributors.
1 History of Industrial Biotransformations – Dreams and Realities (Durda Vasic-Racki).
1.1 From the “Flower of Vinegar” to Recombinant E. Coli – The History of Microbial Biotransformations.
1.2 From Gastric Juice to SweetzymeT – The History of Enzymatic Biotransformations.
1.3 From Wine Bottle to a State-of-the-Art Facility – The History of Biochemical Engineering.
1.4 Advantages of Biotransformations Over Classical Chemistry-Enzymes are proteins, things of beauty and a joy forever.
2 The Enzyme Classification (Christoph Hoh and Murillo Villela FilhoI).
2.1 Enzyme Nomenclature.
2.2 Enzyme Classes.
2.2.1 EC 1 Oxidoreductases.
2.2.2 EC 2 Transferases.
2.2.3 EC 3 Hydrolases.
2.2.4 EC 4 Lyases.
2.2.5 EC 5 Isomerases.
2.2.6 EC 6 Ligases.
3 Retrosynthetic Biocatalysis (Junhua Tao, Alan Pettman, and Andreas Liese).
3.1 Alkanes.
3.2 Alkenes.
3.3 Amines.
3.4 Alcohols.
3.5 Aldehydes.
3.6 Ketones.
3.7 Epoxides.
3.8 Diols.
3.9 Carboxylic Acids.
3.10 Esters.
3.11 Amides.
3.12 Imines.
3.13 Amino Acids.
3.14 Hydroxy Acids.
3.15 a-Hydroxy Ketones.
3.16 b-Hydroxy Aldehydes, Ketones or Carboxylic Acids.
3.17 Cyanohydrins, Hemithioacetals and Hemiaminals.
3.18 Sulfoxides and Sulfones.
3.19 Halides.
3.20 Aromatics (Ring Functionalization).
3.21 Cyclic Compounds.
3.22 Carbohydrates.
3.23 Peroxides.
3.24 Isomers.
3.25 Examples of Retrosynthetic Biotransformations.
3.25.1 Example 1.
3.25.2 Example 2.
4 Optimization of Industrial Enzymes by Molecular Engineering (Thorsten Eggert).
4.1 Introduction.
4.2 Learning from Nature.
4.3 Enzyme Production Using Bacterial Expression Hosts.
4.4 Improvements to Enzymes by Molecular Engineering Techniques.
4.4.1 Rational Enzyme Design.
4.4.2 Directed Evolution.
4.4.3 Random Mutagenesis Methods.
4.5 Identification of Improved Enzyme Variants.
4.6 Conclusions and Future Prospects.
5 Basics of Bioreaction Engineering (Nagaraj N. Rao, Stephan Lütz, Karsten Seelbach, and Andreas Liese).
5.1 Definitions.
5.1.1 Process Definitions.
5.1.2 Definitions of Unit Operations.
5.2 Biocatalyst Kinetics.
5.2.1 Types of Biocatalysts.
5.2.2 Enzyme Structure.
5.2.3 Kinetics.
5.3 Basic Reactor Types and their Modes of Operation.
5.3.1 Mass and Energy Balances.
5.4 Biocatalyst Recycling and Recovery.
5.4.1 Entrapment.
5.4.2 Cross-linking.
5.4.3 Covalent Binding.
5.4.4 Membrane Filtration.
5.5 Reaction Parameters.
5.6 Scale-up of Bioreactors.
5.7 Recent Developments and Trends.
6 Processes (Andreas Liese, Karsten Seelbach, Arne Buchholz, and Jürgen Haberland).
Oxireductases EC 1.
Transferases EC 2.
Hydrolases EC 3.
Lyases EC 4.
Isomerases EC 5.
7 Quantitative Analysis of Industrial Biotransformation (Adrie J. J. Straathof).
Index.
Index of enzyme name.
Index of strain.
Index of company.
Index of starting material.
Index of product.
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