Apoptosis and Cancer Therapy, 2 Volumes

Volume I. Apoptosis signaling
I.1. Death receptor:
-CD95 signaling
-The TRAIL receptor-ligand system
-TNF-induced cell death
-cFLIP
-Dependence receptors and apoptosis
I.2. Mitochondria:
-Role of mitochondrial proteins in apoptosis
-Omi/HtrA2
-Apoptosis inducing factor (AIF)
I.3. Effector systems:
-Caspases
-Apoptosome
I.4. Bcl-2 family:
-Bcl-2 family proteins
-Bax, Bak and Bid
-Puma/Noxa
I.5. IAPs:
-Inhibitor of apoptosis proteins (IAPs)
-Targeting the survivin pathway
I.6. Survival pathways:
-NFkB
-Pi3K/AKT
-Ras/Raf
I.7. Oncogenes/Tumor suppressor genes:
-P53
-P73
-RB
I.8. Modulators:
-Calcium signaling
I.9. Lysosomes and non-apoptotic pathways
I.10. Phagocytosis/
Clearance:
-Phagocytosis of apoptotic cells
-Clearance of apoptotic cells

Volume II. Apoptosis in cancer and cancer therapy
II.1. Models systems:
-Mouse models
II.2. Molecular diagnosis:
-Molecular imaging in cancer research
-Microarrays
II.3. Cellular stress, DNA damage & repair:
-Stress signaling in cancer
-Hypoxia in cancer
-DNA damage-induced apoptosis
-DNA repair
II.4. Molecular targets and therapeutic aspects:
-Therapeutic Modulation of Apoptosis
-Targeting caspases in cancer
-Cancer therapy by reactivation of the p53 apoptosis pathway
-Small molecule inhibitors of IAPs
-Targeting HSP90
-Targeting the PI3K/Akt pathway
-Ceramide Signaling
-HDAC inhibitors
-Exploiting apoptosis pathways for glioblastoma therapy
-Radiation therapy and apoptosis
-Tumor angiogenesis