Preface.

PART I: DEATH RECEPTOR.

1. The Role of CD95/CD95 Ligand Signaling in Apoptosis and Cancer (K. Gülow, et al.).  

2. The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction, Therapeutic Potential for Cancer Treatment and Physiological Function (H. Walczak, et al.).  

3. Mechanisms of Tumor Necrosis Factor-Induced Cell Death (H. Wajant).

4. Cellular FLICE-inhibitory Protein: An Update (O. Micheau).

5. Dependence Receptors and Apoptosis (P. Mehlen & F. Lourenco).

PART II: MITOCHONDRIA.

6. Role of Mitochondrial Proteins in Apoptosis (X. Saelens, et al.).  

7. Omi/HtrA2: A Mitochondrial Serine Protease Regulating Cellular Life and Death (Y. Suzuki & R. Takahashi).

8. Apoptosis-inducing Factor (N. Vahsen & G. Kroemer).

PART III: EFFECTOR SYSTEMS.

9. Caspases: Agents of Defense and Destruction (C. Adrain & S. Martin).

10. The Role of the Apoptosome in Apoptosis and Cancer Therapy (K. Cain).

PART IV: BcL-2 FAMILY.

11. The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy (E. Naik & A. strasser).

12. Bax, Bak and Bid: Key Mediators of Apoptosis (C. Dempsey, et al.).  

13. The BH3-only Proteins Puma and Noxa: Two Brothers in Arms (M. Erlacher, et al.).  

PART V: IAPs.

14. Inhibitor of Apoptosis Proteins (M. Holcik).

15. Targeting the Survivin Pathway for Rational Cancer Therapy (D. Altieri).

PART VI: SURVIVAL PATHWAYS.

16. Nuclear Factor-kB in Apoptosis and Tumorigenesis (F. Greten & M. Karin).

17. Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B (M. Scheid & J. Woodgett).

18. Survival Regulation by Ras and Raf (H. Drexler, et al.).  

PART VII: ONCOGENES/TUMOR SUPPRESSOR GENES.

19. p53-mediated Apoptosis: A Multifaceted Story (D. Speidel & W. Deppert).

20. p73 Affects Cell Fate and Tumorigenesis (S. Ramamdan, et al.).  

21. RB and Cancer (B. Chau, et al.).  

PART VIII: MODULATORS.

22. Calcium Signaling in Apoptosis (S. Orrenius & B. Zhivotovsky).

 PART IX: LYSOSOMES AND NONAPOPTOTIC PATHWAYS.

23. Lysosomes and Nonapoptotic Pathways (T. Kirkegaard-Sørensen, et al.).  

PART X: PHAGOCTOSIS/CLEARANCE.

24. The Role of "Eat Me", "Don't Eat Me" and "Find Me" Signals for the Efficient Removal of Apoptotic Cells (K. Lauber & S. Wesselborg).

25. Apoptotic Cell Clearance by Macrophages: Relevance to Tumor Pathogenesis (C. Gregory & A. Devitt).

VOLUME 2.

PART XI: MODEL SYSYTEMS.

26. Mouse Models in Cancer Research (S. Lee & C. Schmitt).

PART XII: MOLECULAR DIAGNOSIS.

27. Molecular Imaging in Cancer (M. Bhojani, et al.).  

28. Microarray-based Expresson Profiling: From Technological Basics to Diagnostic Perspectives (Y. Syagailo, et al.).  

PART XIII: CELLULAR STRESS, DNA DAMAGE AND REPAIR.

29. Life and Death Decisions in Response to Stress (M. Pinkoski).

30. Hypoxia in Cancer (E. Hammond, et al.).  

31. Apoptosis Induced by DNA-damaging Agents (B. Kaina & W. Roos).

32. DNA Repair (M. Schrauder & L. Wiesmüller).

PART XIV: MOLECULAR TARGETS AND THERAPEUTICS.

33. Therapeutic Modulation of Apoptosis in Cancer Therapy (S. Fulda & K. Debatin).

34. Current Therapeutic Strategies Targetging Caspases in Disease (U. Fischer & K. Schulze-Osthoff).

35. Cancer Therapy by Reactivation of the p53 Apoptosis Pathway (H. Stridh, et al.).  

36. Small-molecule Inhibitors of the Apoptosis Proteins (R. Armstrong, et al.).  

37. Inhibition of the Molecular Chaperone Heat Shock Protein 90 in Cancer: Consequences for the Regulation of Survival Signaling and Induction of Cell Death (P. Clarke, et al.).  

38. Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway (C. Granville, et al.).  

39. Cermide Signaling in Apoptosis and Cancer Therapy (S. Kullmann, et al.).  

40. Histone Deacetylase Inhibitors: Development as Anticancer Agents (P. Marks).

41. Exploiting Apoptosis Pathways for Glioblastoma Therapy (J. Rieger & M. Weller).

42. Radiation Therapy and Apoptosis (V. Jendrossek & C. Belka).

43. Tumor Angiogenesis (J. Becker, et al.).  

Index.